COVID-19 Vaccination and Remdesivir are Associated With Protection From New or Increased Levels of Donor-Specific Antibodies Among Kidney Transplant Recipients Hospitalized With COVID-19.
COVID-19 Vaccination and Remdesivir are Associated With Protection From New or Increased Levels of Donor-Specific Antibodies Among Kidney Transplant Recipients Hospitalized With COVID-19.
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DOI：
10.3389/ti.2022.10626
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
中科院分区：
文献类型：
--
作者：
既往因COVID-19住院的肾移植（KT）患者的同种免疫反应尚未得到充分研究。我们分析了一组112名肾移植受者，他们在COVID-19大流行的前20个月内因SARS-CoV-2检测结果阳性而住院。我们发现，在住院的SARS-CoV-2感染的KT患者中，新的供体特异性抗体（DSA）或先前存在的DSA水平升高的累积发生率为17%。这种风险在感染后延长了8个月。DSA状态的这些变化与晚期同种异体移植物功能障碍有关。在该KT患者队列中，新的或增加的DSA反应的风险因素包括COVID-19诊断前存在循环DSA和移植后时间。感染前接种COVID-19疫苗和感染期间给予Remdesivir均与发生新的或增加的DSA反应的可能性降低相关。这些数据表明，新的或增强的DSA反应经常发生在因COVID-19需要入院的KT患者中，并表明监测、疫苗接种和抗病毒治疗可能是预防这些个体同种免疫的重要工具。
Alloimmune responses in kidney transplant (KT) patients previously hospitalized with COVID-19 are understudied. We analyzed a cohort of 112 kidney transplant recipients who were hospitalized following a positive SARS-CoV-2 test result during the first 20 months of the COVID-19 pandemic. We found a cumulative incidence of 17% for the development of new donor-specific antibodies (DSA) or increased levels of pre-existing DSA in hospitalized SARS-CoV-2-infected KT patients. This risk extended 8 months post-infection. These changes in DSA status were associated with late allograft dysfunction. Risk factors for new or increased DSA responses in this KT patient cohort included the presence of circulating DSA pre-COVID-19 diagnosis and time post-transplantation. COVID-19 vaccination prior to infection and remdesivir administration during infection were each associated with decreased likelihood of developing a new or increased DSA response. These data show that new or enhanced DSA responses frequently occur among KT patients requiring admission with COVID-19 and suggest that surveillance, vaccination, and antiviral therapies may be important tools to prevent alloimmunity in these individuals.
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影响因子：
16.6
作者：
Kokic G;Hillen HS;Tegunov D;Dienemann C;Seitz F;Schmitzova J;Farnung L;Siewert A;Höbartner C;Cramer P
通讯作者：
Cramer P
影响因子：
64.8
作者：
Gaebler C;Wang Z;Lorenzi JCC;Muecksch F;Finkin S;Tokuyama M;Cho A;Jankovic M;Schaefer-Babajew D;Oliveira TY;Cipolla M;Viant C;Barnes CO;Bram Y;Breton G;Hägglöf T;Mendoza P;Hurley A;Turroja M;Gordon K;Millard KG;Ramos V;Schmidt F;Weisblum Y;Jha D;Tankelevich M;Martinez-Delgado G;Yee J;Patel R;Dizon J;Unson-O'Brien C;Shimeliovich I;Robbiani DF;Zhao Z;Gazumyan A;Schwartz RE;Hatziioannou T;Bjorkman PJ;Mehandru S;Bieniasz PD;Caskey M;Nussenzweig MC
通讯作者：
Nussenzweig MC
影响因子：
13.2
作者：
Heerspink, Hiddo J. Lambers;Tighiouart, Hocine;Inker, Lesley A.
通讯作者：
Inker, Lesley A.
影响因子：
13.6
作者：
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通讯作者：
Sarnak, Mark J.
影响因子：
8.8
作者：
Heldman, Madeleine R.;Kates, Olivia S.;Limaye, Ajit P.
通讯作者：
Limaye, Ajit P.