Knowledge about hereditary nonpolyposis colorectal cancer; mutation carriers and physicians at equal levels.
Knowledge about hereditary nonpolyposis colorectal cancer; mutation carriers and physicians at equal levels.
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关于遗传性非型性结直肠癌的知识；突变携带者和医生相等的水平。
DOI：
10.1186/1471-2350-10-30
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发表时间：
2009-03-26
影响因子：
--
通讯作者：
Nilbert M
中科院分区：
文献类型：
--
作者：
Domanska K;Carlsson C;Bendahl PO;Nilbert M
识别和适当的管理个体的遗传性非息肉病性结直肠癌（HNPCC）的风险是至关重要的，因为监测计划降低发病率和死亡率。我们调查了高危人群和外科、妇科和肿瘤科医生对HNPCC关键特征的认识。数据收集使用问卷调查，回答了67突变携带者和102名医生从瑞典南部的医疗保健地区。这些陈述与结直肠癌、遗传和监测有关，医生还被问及有关癌症风险和监测策略的问题。两组都很好地回答了关于结直肠癌风险、监测和基因检测的问题，而关于遗传和HNPCC相关癌症风险的回答则不太准确。只有一半的家庭成员和三分之一的医生正确估计了遗传HNPCC易感突变的风险。在家庭成员中，年轻（<57岁），女性和最近的遗传咨询与更好的结果显着相关。医生们普遍低估了HNPCC相关癌症的风险，四分之三的人建议监测的起始年龄比建议的要晚。在高危人群和医生中发现HNPCC关键特征的相似知识水平反映了医生在保持最新遗传性癌症方面面临的挑战，并可能对临床管理和与HNPCC家族成员的专业关系产生影响。
Identification and adequate management of individuals at risk for hereditary nonpolyposis colorectal cancer (HNPCC) is crucial since surveillance programmes reduce morbidity and mortality. We investigated knowledge about key features of HNPCC in at risk individuals and physicians in surgery, gynecology and oncology. Data were collected using a questionnaire which was answered by 67 mutation carriers and 102 physicians from the southern Swedish health care region. The statements were related to colorectal cancer, heredity and surveillance and the physicians were also asked questions about cancer risks and surveillance strategies. Both groups answered questions on colorectal cancer risk, surveillance and genetic testing well, whereas answers about inheritance and risks for HNPCC associated cancer were less accurate. Only half of the family members and one third of the physicians correctly estimated the risk to inherit an HNPCC predisposing mutation. Among family members, young age (<57 years), female sex and recent genetic counseling significantly correlated with better results. Physicians generally underestimated the risk of HNPCC associated cancers and three out of four suggested a later starting age for surveillance than recommended. The finding of similar levels of knowledge about key features of HNPCC in at risk individuals and physicians reflect the challenge physicians face in keeping up to date on hereditary cancer and may have implications for the clinical management and professional relations with HNPCC family members.
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影响因子：
45.3
作者：
Hadley, DW;Jenkins, JF;Palmer, CGS
通讯作者：
Palmer, CGS
影响因子：
4.7
作者：
Lancaster, Johnathan M.;Powell, C. Bethan;Herzog, Thomas J.
通讯作者：
Herzog, Thomas J.
影响因子：
2.2
作者：
Murphy, H. R.;Armstrong, R.;Greenhalgh, K. L.
通讯作者：
Greenhalgh, K. L.
影响因子：
2
作者：
Tinley, ST;Houfek, J;Lynch, HT
通讯作者：
Lynch, HT
影响因子：
9.8
作者：
Schroy, PC;Barrison, AF;Geller, AC
通讯作者：
Geller, AC