Effects of the tropical ginger compound,1'-acetoxychavicol acetate, against tumor promotion in K5.Stat3C transgenic mice.
Effects of the tropical ginger compound,1'-acetoxychavicol acetate, against tumor promotion in K5.Stat3C transgenic mice.
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DOI：
10.1186/1756-9966-31-57
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发表时间：
2012-06-15
期刊：
影响因子：
--
通讯作者：
Kleiner-Hancock HE
中科院分区：
文献类型：
--
作者：
Batra V;Syed Z;Gill JN;Coburn MA;Adegboyega P;DiGiovanni J;Mathis JM;Shi R;Clifford JL;Kleiner-Hancock HE
本研究的目的是确定热带姜衍生的化合物1 '-乙酰氧基胡椒酚乙酸酯（ACA）是否抑制K5.Stat3C小鼠中的皮肤肿瘤促进。在一项为期两周的研究中，野生型（WT）和K5.Stat3C小鼠用载体、ACA、高良姜提取物或醋酸氟轻松（FA）和十四酰佛波醇乙酸酯（TPA）共处理，仅高良姜提取物和FA抑制TPA诱导的皮肤过度增殖和湿重。这些药物均不能有效抑制p-Tyr 705 Stat 3表达。然而，ACA和FA对K5.Stat3C小鼠的皮肤肿瘤发生显示出有希望的抑制作用。ACA还抑制磷酸化p65 NF-κB活化，提示其作用的潜在机制。
The purpose of the current study was to determine whether a tropical ginger derived compound 1’-acetoxychavicol acetate (ACA), suppresses skin tumor promotion in K5.Stat3C mice. In a two-week study in which wild-type (WT) and K5.Stat3C mice were co-treated with either vehicle, ACA, galanga extract, or fluocinolone acetonide (FA) and tetradecanoyl phorbol acetate (TPA), only the galanga extract and FA suppressed TPA-induced skin hyperproliferation and wet weight. None of these agents were effective at suppressing p-Tyr705Stat3 expression. However, ACA and FA showed promising inhibitory effects against skin tumorigenesis in K5.Stat3C mice. ACA also suppressed phospho-p65 NF-κB activation, suggesting a potential mechanism for its action.
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影响因子：
11.2
作者：
Aziz, Moammir H.;Manoharan, Herbert T.;Verma, Ajit K.
通讯作者：
Verma, Ajit K.
影响因子：
3.5
作者：
Campbell, Cheryl T.;Prince, Misty;Kleiner, Heather E.
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影响因子：
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作者：
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通讯作者：
Matsui-Yuasa, I
DOI：
10.1073/pnas.0510422103
发表时间：
2006-02-14
影响因子：
11.1
作者：
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通讯作者：
Fuchs, E
影响因子：
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作者：
Ito, K;Nakazato, T;Kizaki, M
通讯作者：
Kizaki, M