Balance telerehabilitation and wearable technology for people with Parkinson's disease (TelePD trial).
Balance telerehabilitation and wearable technology for people with Parkinson's disease (TelePD trial).
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DOI：
10.1186/s12883-023-03403-3
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发表时间：
2023-10-13
期刊：
影响因子：
2.6
通讯作者：
King, Laurie A.
中科院分区：
文献类型：
--
作者：
Silva-Batista, Carla;Wilhelm, Jennifer L.;Scanlan, Kathleen T.;Stojak, Margaret;Carlson-Kuhta, Patricia;Chen, Siting;Liu, William;de la Huerta, Tomas Nicolas Garcia;Horak, Fay B.;Mancini, Martina;King, Laurie A.
平衡障碍导致福尔斯，是帕金森病（PD）的主要症状之一。远程康复在PD患者中越来越普遍;然而，平衡在虚拟评估和治疗方面尤其具有挑战性。PD患者平衡的虚拟评估和虚拟治疗的可行性和有效性尚不清楚。本研究方案有三个目的：I）确定虚拟平衡和步态评估是否（仪器化L形移动测试）与可穿戴传感器可以预测一个黄金标准，在人的平衡临床评估，迷你平衡评估系统测试（Mini-BESTest）; II）探讨12次平衡远程康复和无监督家庭锻炼对平衡，步态，执行功能，和临床量表;和III）探索平衡远程康复后的改善是否转移到日常生活中的移动性，如通过佩戴7天的带有惯性传感器的仪器袜子所测量的。TelePD试验是一项前瞻性、单中心、平行组、单盲、初探性、随机、对照试验。本试验将入组80名符合条件的PD患者。参与者将以1：1的比例随机接受家庭平衡练习：1）平衡远程康复（实验组，n = 40）或2）无监督练习（对照组，n = 40）。两组都将在家中进行12次锻炼，每次60分钟。主要结局将是Mini-BESTest。次要结局将是规定任务的上半身和下半身步态指标（仪器化L形移动性测试）; 7天内使用袜子中的可穿戴传感器进行日常生活移动性测量，仪器化执行功能测试和临床量表。基线测试和7天的日常生活活动测量将在干预期前后进行。TelePD试验将是第一个探索使用可穿戴传感器的平衡和步态测量远程评估平衡的有用性，PD患者平衡远程康复的可行性和有效性，以及远程康复后平衡改善的转化日常生活流动性。这些结果将有助于开发一种更有效的基于家庭的平衡远程康复和虚拟评估，可以远程用于平衡障碍的人。本试验在ClinicalTrials.gov上前瞻性注册（NCT 05680597）。在线版本包含补充材料，可通过10.1186/s12883-023-03403-3获取。
Balance impairments, that lead to falls, are one of the main symptoms of Parkinson’s disease (PD). Telerehabilitation is becoming more common for people with PD; however, balance is particularly challenging to assess and treat virtually. The feasibility and efficacy of virtual assessment and virtual treatment of balance in people with PD are unknown. The present study protocol has three aims: I) to determine if a virtual balance and gait assessment (instrumented L-shape mobility test) with wearable sensors can predict a gold-standard, in-person clinical assessment of balance, the Mini Balance Evaluation Systems Test (Mini-BESTest); II) to explore the effects of 12 sessions of balance telerehabilitation and unsupervised home exercises on balance, gait, executive function, and clinical scales; and III) to explore if improvements after balance telerehabilitation transfer to daily-life mobility, as measured by instrumented socks with inertial sensors worn for 7 days. The TelePD Trial is a prospective, single-center, parallel-group, single-blind, pilot, randomized, controlled trial. This trial will enroll 80 eligible people with PD. Participants will be randomized at a 1:1 ratio into receiving home-based balance exercises in either: 1) balance telerehabilitation (experimental group, n = 40) or 2) unsupervised exercises (control group, n = 40). Both groups will perform 12 sessions of exercise at home that are 60 min long. The primary outcome will be Mini-BESTest. The secondary outcomes will be upper and lower body gait metrics from a prescribed task (instrumented L-shape mobility test); daily-life mobility measures over 7 days with wearable sensors in socks, instrumented executive function tests, and clinical scales. Baseline testing and 7 days of daily-life mobility measurement will occur before and after the intervention period. The TelePD Trial will be the first to explore the usefulness of using wearable sensor-based measures of balance and gait remotely to assess balance, the feasibility and efficacy of balance telerehabilitation in people with PD, and the translation of balance improvements after telerehabilitation to daily-life mobility. These results will help to develop a more effective home-based balance telerehabilitation and virtual assessment that can be used remotely in people with balance impairments. This trial was prospectively registered on ClinicalTrials.gov (NCT05680597). The online version contains supplementary material available at 10.1186/s12883-023-03403-3.
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