MicroRNAs and osteocytes.

MicroRNAs and osteocytes.
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微小核糖核酸与骨细胞

DOI:
10.1016/j.bone.2021.115994
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发表时间:
2021-09
期刊:
影响因子:
4.1
通讯作者:
Wallace JM
Wallace JM
中科院分区:
医学2区
文献类型:
--
作者:
Plotkin LI;Wallace JM

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microRNA在20世纪90年代初被发现,据信调节了大约30%的人类基因组。microRNA在骨细胞中的作用最早于2007年在一份手稿中报道,该手稿显示microRNA- 223对体外破骨细胞分化至关重要,同年有一些研究报道了microRNA在成骨细胞中的作用。2010年首次报道了microRNA在骨细胞中的作用,发现microRNA簇23 a ~ 27 a ~24-2调控骨细胞的分化。从那时起,很少有研究描述了这些18-25个核苷酸的非编码RNA对骨细胞生物学的作用,报告骨细胞既作为生产者又作为microRNA作用的靶点。本文就microRNA对骨细胞生物学的影响作一综述。
microRNAs, identified in the early 1990s, are believed to regulate approximately 30% of the human genome. The role of microRNA in bone cells was first reported in 2007 in a manuscript showing that microRNA- 223 is essential for osteoclast differentiation in vitro, and a few studies reported a role of microRNAs in osteoblasts the same year. The first report of microRNA actions in osteocytes was published in 2010, in which it was demonstrated that the microRNA cluster 23a~27a~24–2 regulates osteocyte differentiation. Since then, few studies have described the role of these 18–25-nucleotide non-coding RNAs on osteocyte biology, reporting osteocytes both as producers and as targets of the actions of microRNAs. We review here the current knowledge on the effects of microRNAs on osteocyte biology.
DOI: 10.1371/journal.pone.0058796
发表时间: 2013
期刊: PloS one
影响因子: 3.7
作者:
Eguchi T;Watanabe K;Hara ES;Ono M;Kuboki T;Calderwood SK
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