Longitudinal change in health-related quality of life after intensity-modulated radiation monotherapy for clinically localized prostate cancer.
Longitudinal change in health-related quality of life after intensity-modulated radiation monotherapy for clinically localized prostate cancer.
复制标题
DOI：
10.1007/s11136-013-0603-6
复制
发表时间：
2014-06
影响因子：
3.5
通讯作者：
Yonese, Junji
中科院分区：
文献类型：
--
作者：
Yamamoto, Shinya;Fujii, Yasuhisa;Masuda, Hitoshi;Urakami, Shinji;Saito, Kazutaka;Kozuka, Takuyo;Oguchi, Masahiko;Fukui, Iwao;Yonese, Junji
本研究的目的是评估局部前列腺癌（PCA）患者接受调强放疗（IMRT）单药治疗后一般和疾病特异性健康相关生活质量（HRQOL）指数的纵向变化。 在2006年至2010年期间，91例局部PCA患者接受了IMRT单药治疗，并入选本前瞻性研究。在基线和调强放疗后3、6、12和24个月，使用身体（PCS）和心理健康总评（MCS）估计总体和前列腺特异性HRQOL，使用医学结局研究8项简表健康调查和扩展前列腺癌综合指数（EPIC）计算。2年来，EPIC评分在泌尿领域、激素功能和烦恼的所有子量表中均无显著变化。调强放疗后肠道和性功能评分下降，并且没有恢复到基线水平（分别为p = 0.006和< 0.001）。PCS在IMRT后3个月开始下降，然后在24个月时恢复到基线评分。相比之下，MCS评分在IMRT后开始显著增加，此后评分保持不变，直到24个月（p < 0.001）。在多变量logistic回归分析中，基线时的泌尿功能（p = 0.003）和性功能（p = 0.0005）被确定为IMRT后24个月EPIC泌尿刺激/阻塞评分和性功能的重要预测因素。泌尿功能，包括刺激/梗阻症状和激素功能，不受调强放射治疗的影响。然而，肠道和性功能下降后调强放疗。这些发现将为考虑IMRT的PCA患者提供重要信息。
The purpose of the study is to assess longitudinal changes in general and disease-specific health-related quality-of-life (HRQOL) indices after intensity-modulated radiotherapy (IMRT) monotherapy for patients with localized prostate cancer (PCA). Between 2006 and 2010, 91 patients with localized PCA underwent IMRT monotherapy and were enrolled into this prospective study. At baseline, and at 3, 6, 12, and 24 months after IMRT, the general and prostate-specific HRQOL were estimated using physical (PCS) and mental component summaries (MCS) calculated using the Medical Outcomes Study 8-Item Short Form Health Survey and Expanded Prostate Cancer Index Composite (EPIC). For 2 years, there were no significant changes in EPIC scores in all subscales of urinary domain, hormonal function, and bother. Bowel and sexual function scores decreased after IMRT and did not return to those at baseline (p = 0.006 and < 0.001, respectively). PCS began to decrease at 3 months after IMRT and then returned to the baseline score at 24 months. In contrast, the MCS score began to significantly increase after IMRT, and thereafter the score remained constant until 24 months (p < 0.001). On multivariate logistic regression analysis, urinary (p = 0.003) and sexual functions (p = 0.0005) at baseline were identified as significant predictors of EPIC urinary irritative/obstructive score and sexual function at 24 months after IMRT. Urinary function, including irritative/obstruction symptoms and hormonal function, was not affected by IMRT. However, bowel and sexual function decreased after IMRT. These findings will provide important information for PCA patients considering IMRT.
登录
查看更多内容
影响因子：
2.6
作者：
Sugimoto, Mikio;Takegami, Misa;Kakehi, Yoshiyuki
通讯作者：
Kakehi, Yoshiyuki
影响因子：
8.4
作者：
Ataman, F;Zurlo, A;Bolla, M
通讯作者：
Bolla, M
DOI：
10.1016/j.ijrobp.2007.04.013
发表时间：
2007-11-01
影响因子：
7
作者：
Lips, Irene;Dehnad, Human;van Vulpen, Marco
通讯作者：
van Vulpen, Marco
影响因子：
120.7
作者：
Sheets, Nathan C.;Goldin, Gregg H.;Chen, Ronald C.
通讯作者：
Chen, Ronald C.
影响因子：
8.4
作者：
Mangar, SA;Huddart, RA;Horwich, A
通讯作者：
Horwich, A