Basophils and allergic inflammation.
Basophils and allergic inflammation.
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DOI：
10.1016/j.jaci.2013.07.046
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发表时间：
2013-10
影响因子：
14.2
通讯作者：
Artis, David
中科院分区：
文献类型：
--
作者：
Siracusa, Mark C.;Kim, Brian S.;Spergel, Jonathan M.;Artis, David
关键词：
嗜碱性粒细胞是由Paul埃利希在1879年发现的，代表哺乳动物中丰度最低的粒细胞群体。嗜碱性粒细胞的相对罕见性及其与肥大细胞的表型相似性导致该细胞谱系在历史上被忽视，无论是临床还是实验。然而，最近在人类和小鼠系统中的研究表明，嗜碱性粒细胞执行非冗余效应子功能，并显著促进TH2烟碱介导的炎症的发展和进展。虽然小鼠和人类嗜碱性粒细胞的潜在功能引起了一些争议，最近的遗传学方法表明，嗜碱性粒细胞可以迁移到淋巴组织，并在某些情况下，与其他免疫细胞合作，以促进最佳的TH2细胞因子在体内的反应。本文提供了一个简短的历史观点嗜碱性粒细胞相关的研究，并讨论了最近的研究，已经确定了以前不受重视的分子和途径，调节嗜碱性粒细胞的发展，激活和功能的背景下过敏性炎症。此外，我们强调了嗜碱性粒细胞的独特效应功能，并讨论了它们对人类疾病中过敏性炎症的发展和发病机制的贡献。最后，我们讨论了靶向嗜碱性粒细胞在预防或减轻过敏性炎症的发展和进展中的治疗潜力。
Basophils were discovered by Paul Ehrlich in 1879 and represent the least abundant granulocyte population in mammals. The relative rarity of basophils and their phenotypic similarities with mast cells resulted in this cell lineage being historically overlooked, both clinically and experimentally. However, recent studies in humans and murine systems have shown that basophils perform non-redundant effector functions and significantly contribute to the development and progression of TH2 cytokine-mediated inflammation. Although the potential functions of murine and human basophils have provoked some controversy, recent genetic approaches indicate that basophils can migrate into lymphoid tissues and, in some circumstances, cooperate with other immune cells to promote optimal TH2 cytokine responses in vivo. This article provides a brief historical perspective on basophil-related research and discusses recent studies that have identified previously unappreciated molecules and pathways that regulate basophil development, activation and function in the context of allergic inflammation. Further, we highlight the unique effector functions of basophils and discuss their contributions to the development and pathogenesis of allergic inflammation in human disease. Finally, we discuss the therapeutic potential of targeting basophils in preventing or alleviating the development and progression of allergic inflammation.
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影响因子：
3.7
作者：
Chen ZG;Zhang TT;Li HT;Chen FH;Zou XL;Ji JZ;Chen H
通讯作者：
Chen H
使用鼻内猫过敏原激发，奥马珠单抗对嗜碱性粒细胞和肥大细胞反应的影响。
影响因子：
14.2
作者：
Eckman, John A.;Sterba, Patricia M.;Kelly, Denise;Alexander, Val;Liu, Mark C.;Bochner, Bruce S.;MacGlashan, Donald W., Jr.;Saini, Sarbjit S.
通讯作者：
Saini, Sarbjit S.
影响因子：
14.2
作者：
Chen, YH;Bieneman, AP;Schroeder, JT
通讯作者：
Schroeder, JT
影响因子：
82.9
作者：
通讯作者：
--
影响因子：
12.4
作者：
Eckl-Dorna J;Ellinger A;Blatt K;Ghanim V;Steiner I;Pavelka M;Valent P;Valenta R;Niederberger V
通讯作者：
Niederberger V