Erratum: Large meta-analysis of genome-wide association studies identifies five loci for lean body mass.
Erratum: Large meta-analysis of genome-wide association studies identifies five loci for lean body mass.
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DOI：
10.1038/s41467-017-01008-2
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发表时间：
2017-11-07
影响因子：
16.6
通讯作者：
Kiel DP
中科院分区：
文献类型：
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作者：
Zillikens MC;Demissie S;Hsu YH;Yerges-Armstrong LM;Chou WC;Stolk L;Livshits G;Broer L;Johnson T;Koller DL;Kutalik Z;Luan J;Malkin I;Ried JS;Smith AV;Thorleifsson G;Vandenput L;Hua Zhao J;Zhang W;Aghdassi A;Åkesson K;Amin N;Baier LJ;Barroso I;Bennett DA;Bertram L;Biffar R;Bochud M;Boehnke M;Borecki IB;Buchman AS;Byberg L;Campbell H;Campos Obanda N;Cauley JA;Cawthon PM;Cederberg H;Chen Z;Cho NH;Jin Choi H;Claussnitzer M;Collins F;Cummings SR;De Jager PL;Demuth I;Dhonukshe-Rutten RAM;Diatchenko L;Eiriksdottir G;Enneman AW;Erdos M;Eriksson JG;Eriksson J;Estrada K;Evans DS;Feitosa MF;Fu M;Garcia M;Gieger C;Girke T;Glazer NL;Grallert H;Grewal J;Han BG;Hanson RL;Hayward C;Hofman A;Hoffman EP;Homuth G;Hsueh WC;Hubal MJ;Hubbard A;Huffman KM;Husted LB;Illig T;Ingelsson E;Ittermann T;Jansson JO;Jordan JM;Jula A;Karlsson M;Khaw KT;Kilpeläinen TO;Klopp N;Kloth JSL;Koistinen HA;Kraus WE;Kritchevsky S;Kuulasmaa T;Kuusisto J;Laakso M;Lahti J;Lang T;Langdahl BL;Launer LJ;Lee JY;Lerch MM;Lewis JR;Lind L;Lindgren C;Liu Y;Liu T;Liu Y;Ljunggren Ö;Lorentzon M;Luben RN;Maixner W;McGuigan FE;Medina-Gomez C;Meitinger T;Melhus H;Mellström D;Melov S;Michaëlsson K;Mitchell BD;Morris AP;Mosekilde L;Newman A;Nielson CM;O'Connell JR;Oostra BA;Orwoll ES;Palotie A;Parker SCJ;Peacock M;Perola M;Peters A;Polasek O;Prince RL;Räikkönen K;Ralston SH;Ripatti S;Robbins JA;Rotter JI;Rudan I;Salomaa V;Satterfield S;Schadt EE;Schipf S;Scott L;Sehmi J;Shen J;Soo Shin C;Sigurdsson G;Smith S;Soranzo N;Stančáková A;Steinhagen-Thiessen E;Streeten EA;Styrkarsdottir U;Swart KMA;Tan ST;Tarnopolsky MA;Thompson P;Thomson CA;Thorsteinsdottir U;Tikkanen E;Tranah GJ;Tuomilehto J;van Schoor NM;Verma A;Vollenweider P;Völzke H;Wactawski-Wende J;Walker M;Weedon MN;Welch R;Wichmann HE;Widen E;Williams FMK;Wilson JF;Wright NC;Xie W;Yu L;Zhou Y;Chambers JC;Döring A;van Duijn CM;Econs MJ;Gudnason V;Kooner JS;Psaty BM;Spector TD;Stefansson K;Rivadeneira F;Uitterlinden AG;Wareham NJ;Ossowski V;Waterworth D;Loos RJF;Karasik D;Harris TB;Ohlsson C;Kiel DP
精瘦的身体质量主要由骨骼肌组成，对健康衰老很重要。我们对全身(20个欧洲血统，n=38,292)和附件(手臂和腿)瘦体重(n=28,330)进行了全基因组相关性研究，使用双能X射线吸收测量仪或生物电阻抗分析，调整了性别、年龄、身高和脂肪质量。21个单核苷酸多态与瘦体重显著相关，要么是基因组范围(p<；5×10−8)，要么是建议的基因组范围(p<；2.3×10−6)。来自33个群体的63,475名个体(欧洲血统的47,227名)和来自25个群体的45,090名(欧洲血统的42,360名)附件瘦体质量的受试者在HSD17B11、VCAN、ADAMTSL3、IRS1和FTO的5个单核苷酸多态和在VCAN、ADAMTSL3和IRS1的附件瘦体质量的3个单核苷酸多态中成功复制。我们的发现为瘦体重的遗传学提供了新的见解。
Lean body mass, consisting mostly of skeletal muscle, is important for healthy aging. We performed a genome-wide association study for whole body (20 cohorts of European ancestry with n= 38,292) and appendicular (arms and legs) lean body mass (n= 28,330) measured using dual energy X-ray absorptiometry or bioelectrical impedance analysis, adjusted for sex, age, height, and fat mass. Twenty-one single-nucleotide polymorphisms were significantly associated with lean body mass either genome wide (p< 5× 10− 8) or suggestively genome wide (p< 2.3× 10− 6). Replication in 63,475 (47,227 of European ancestry) individuals from 33 cohorts for whole body lean body mass and in 45,090 (42,360 of European ancestry) subjects from 25 cohorts for appendicular lean body mass was successful for five single-nucleotide polymorphisms in/near HSD17B11, VCAN, ADAMTSL3, IRS1, and FTO for total lean body mass and for three single-nucleotide polymorphisms in/near VCAN, ADAMTSL3, and IRS1 for appendicular lean body mass. Our findings provide new insight into the genetics of lean body mass.
影响因子：
16.6
作者：
Zillikens MC;Demissie S;Hsu YH;Yerges-Armstrong LM;Chou WC;Stolk L;Livshits G;Broer L;Johnson T;Koller DL;Kutalik Z;Luan J;Malkin I;Ried JS;Smith AV;Thorleifsson G;Vandenput L;Hua Zhao J;Zhang W;Aghdassi A;Åkesson K;Amin N;Baier LJ;Barroso I;Bennett DA;Bertram L;Biffar R;Bochud M;Boehnke M;Borecki IB;Buchman AS;Byberg L;Campbell H;Campos Obanda N;Cauley JA;Cawthon PM;Cederberg H;Chen Z;Cho NH;Jin Choi H;Claussnitzer M;Collins F;Cummings SR;De Jager PL;Demuth I;Dhonukshe-Rutten RAM;Diatchenko L;Eiriksdottir G;Enneman AW;Erdos M;Eriksson JG;Eriksson J;Estrada K;Evans DS;Feitosa MF;Fu M;Garcia M;Gieger C;Girke T;Glazer NL;Grallert H;Grewal J;Han BG;Hanson RL;Hayward C;Hofman A;Hoffman EP;Homuth G;Hsueh WC;Hubal MJ;Hubbard A;Huffman KM;Husted LB;Illig T;Ingelsson E;Ittermann T;Jansson JO;Jordan JM;Jula A;Karlsson M;Khaw KT;Kilpeläinen TO;Klopp N;Kloth JSL;Koistinen HA;Kraus WE;Kritchevsky S;Kuulasmaa T;Kuusisto J;Laakso M;Lahti J;Lang T;Langdahl BL;Launer LJ;Lee JY;Lerch MM;Lewis JR;Lind L;Lindgren C;Liu Y;Liu T;Liu Y;Ljunggren Ö;Lorentzon M;Luben RN;Maixner W;McGuigan FE;Medina-Gomez C;Meitinger T;Melhus H;Mellström D;Melov S;Michaëlsson K;Mitchell BD;Morris AP;Mosekilde L;Newman A;Nielson CM;O'Connell JR;Oostra BA;Orwoll ES;Palotie A;Parker SCJ;Peacock M;Perola M;Peters A;Polasek O;Prince RL;Räikkönen K;Ralston SH;Ripatti S;Robbins JA;Rotter JI;Rudan I;Salomaa V;Satterfield S;Schadt EE;Schipf S;Scott L;Sehmi J;Shen J;Soo Shin C;Sigurdsson G;Smith S;Soranzo N;Stančáková A;Steinhagen-Thiessen E;Streeten EA;Styrkarsdottir U;Swart KMA;Tan ST;Tarnopolsky MA;Thompson P;Thomson CA;Thorsteinsdottir U;Tikkanen E;Tranah GJ;Tuomilehto J;van Schoor NM;Verma A;Vollenweider P;Völzke H;Wactawski-Wende J;Walker M;Weedon MN;Welch R;Wichmann HE;Widen E;Williams FMK;Wilson JF;Wright NC;Xie W;Yu L;Zhou Y;Chambers JC;Döring A;van Duijn CM;Econs MJ;Gudnason V;Kooner JS;Psaty BM;Spector TD;Stefansson K;Rivadeneira F;Uitterlinden AG;Wareham NJ;Ossowski V;Waterworth D;Loos RJF;Karasik D;Harris TB;Ohlsson C;Kiel DP
通讯作者：
Kiel DP