Large meta-analysis of genome-wide association studies identifies five loci for lean body mass.
Large meta-analysis of genome-wide association studies identifies five loci for lean body mass.
复制标题
DOI：
10.1038/s41467-017-00031-7
复制
发表时间：
2017-07-19
影响因子：
16.6
通讯作者：
Kiel DP
中科院分区：
文献类型：
--
作者：
Zillikens MC;Demissie S;Hsu YH;Yerges-Armstrong LM;Chou WC;Stolk L;Livshits G;Broer L;Johnson T;Koller DL;Kutalik Z;Luan J;Malkin I;Ried JS;Smith AV;Thorleifsson G;Vandenput L;Hua Zhao J;Zhang W;Aghdassi A;Åkesson K;Amin N;Baier LJ;Barroso I;Bennett DA;Bertram L;Biffar R;Bochud M;Boehnke M;Borecki IB;Buchman AS;Byberg L;Campbell H;Campos Obanda N;Cauley JA;Cawthon PM;Cederberg H;Chen Z;Cho NH;Jin Choi H;Claussnitzer M;Collins F;Cummings SR;De Jager PL;Demuth I;Dhonukshe-Rutten RAM;Diatchenko L;Eiriksdottir G;Enneman AW;Erdos M;Eriksson JG;Eriksson J;Estrada K;Evans DS;Feitosa MF;Fu M;Garcia M;Gieger C;Girke T;Glazer NL;Grallert H;Grewal J;Han BG;Hanson RL;Hayward C;Hofman A;Hoffman EP;Homuth G;Hsueh WC;Hubal MJ;Hubbard A;Huffman KM;Husted LB;Illig T;Ingelsson E;Ittermann T;Jansson JO;Jordan JM;Jula A;Karlsson M;Khaw KT;Kilpeläinen TO;Klopp N;Kloth JSL;Koistinen HA;Kraus WE;Kritchevsky S;Kuulasmaa T;Kuusisto J;Laakso M;Lahti J;Lang T;Langdahl BL;Launer LJ;Lee JY;Lerch MM;Lewis JR;Lind L;Lindgren C;Liu Y;Liu T;Liu Y;Ljunggren Ö;Lorentzon M;Luben RN;Maixner W;McGuigan FE;Medina-Gomez C;Meitinger T;Melhus H;Mellström D;Melov S;Michaëlsson K;Mitchell BD;Morris AP;Mosekilde L;Newman A;Nielson CM;O'Connell JR;Oostra BA;Orwoll ES;Palotie A;Parker SCJ;Peacock M;Perola M;Peters A;Polasek O;Prince RL;Räikkönen K;Ralston SH;Ripatti S;Robbins JA;Rotter JI;Rudan I;Salomaa V;Satterfield S;Schadt EE;Schipf S;Scott L;Sehmi J;Shen J;Soo Shin C;Sigurdsson G;Smith S;Soranzo N;Stančáková A;Steinhagen-Thiessen E;Streeten EA;Styrkarsdottir U;Swart KMA;Tan ST;Tarnopolsky MA;Thompson P;Thomson CA;Thorsteinsdottir U;Tikkanen E;Tranah GJ;Tuomilehto J;van Schoor NM;Verma A;Vollenweider P;Völzke H;Wactawski-Wende J;Walker M;Weedon MN;Welch R;Wichmann HE;Widen E;Williams FMK;Wilson JF;Wright NC;Xie W;Yu L;Zhou Y;Chambers JC;Döring A;van Duijn CM;Econs MJ;Gudnason V;Kooner JS;Psaty BM;Spector TD;Stefansson K;Rivadeneira F;Uitterlinden AG;Wareham NJ;Ossowski V;Waterworth D;Loos RJF;Karasik D;Harris TB;Ohlsson C;Kiel DP
瘦体重，主要由骨骼肌组成，对健康衰老很重要。我们对全身（20个欧洲血统队列，n = 38，292）和四肢（手臂和腿）瘦体重（n = 28，330）进行了全基因组关联研究，使用双能X射线吸收测定法或生物电阻抗分析进行测量，调整性别，年龄，身高和脂肪量。21个单核苷酸多态性与瘦体重显著相关，无论是在全基因组范围内（p < 5 × 10−8）还是在全基因组范围内（p < 2.3 × 10−6）。复制63，475（47，227名欧洲血统）来自33个队列的个体的全身瘦体重和45，090名来自25个队列的42，360名欧洲血统受试者的非正式瘦体重成功获得了5个单核苷酸多态性，分别位于或接近HSD 17 B11、VCAN、ADAMTSL 3、IRS 1、和FTO的总瘦体重和三个单核苷酸多态性在/附近的VCAN，ADAMTSL 3，和IRS 1的approximular瘦体重。我们的发现为瘦体重的遗传学提供了新的见解。瘦体重是一种高度遗传的性状，与各种健康状况有关。在这里，基尔和他的同事进行了一项全身瘦体重的全基因组关联研究的荟萃分析，发现五个新的遗传位点显着相关。
Lean body mass, consisting mostly of skeletal muscle, is important for healthy aging. We performed a genome-wide association study for whole body (20 cohorts of European ancestry with n = 38,292) and appendicular (arms and legs) lean body mass (n = 28,330) measured using dual energy X-ray absorptiometry or bioelectrical impedance analysis, adjusted for sex, age, height, and fat mass. Twenty-one single-nucleotide polymorphisms were significantly associated with lean body mass either genome wide (p < 5 × 10−8) or suggestively genome wide (p < 2.3 × 10−6). Replication in 63,475 (47,227 of European ancestry) individuals from 33 cohorts for whole body lean body mass and in 45,090 (42,360 of European ancestry) subjects from 25 cohorts for appendicular lean body mass was successful for five single-nucleotide polymorphisms in/near HSD17B11, VCAN, ADAMTSL3, IRS1, and FTO for total lean body mass and for three single-nucleotide polymorphisms in/near VCAN, ADAMTSL3, and IRS1 for appendicular lean body mass. Our findings provide new insight into the genetics of lean body mass. Lean body mass is a highly heritable trait and is associated with various health conditions. Here, Kiel and colleagues perform a meta-analysis of genome-wide association studies for whole body lean body mass and find five novel genetic loci to be significantly associated.
登录
查看更多内容
影响因子：
30.8
作者：
通讯作者：
--
影响因子：
6.2
作者：
Arden, NK;Spector, TD
通讯作者：
Spector, TD
DOI：
10.1038/oby.2005.42
发表时间：
2005-02-01
期刊：
OBESITY RESEARCH
影响因子：
--
作者：
Hsu, FC;Lenchik, L;Carr, JJ
通讯作者：
Carr, JJ
拷贝数变异的全基因组关联研究将 gremlin1 确定为瘦体重的候选基因
影响因子：
3.5
作者：
通讯作者：
--
影响因子：
7.7
作者：
Hanson RL;Muller YL;Kobes S;Guo T;Bian L;Ossowski V;Wiedrich K;Sutherland J;Wiedrich C;Mahkee D;Huang K;Abdussamad M;Traurig M;Weil EJ;Nelson RG;Bennett PH;Knowler WC;Bogardus C;Baier LJ
通讯作者：
Baier LJ