Nogo-66 receptor at the gap junctions between pituicytes of the rat

Nogo-66 receptor at the gap junctions between pituicytes of the rat
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大鼠垂体细胞间隙连接处的 Nogo-66 受体

DOI:
10.1097/00001756-200604240-00010
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发表时间:
2006-04
期刊:
影响因子:
1.7
通讯作者:
--
中科院分区:
医学4区
文献类型:
--
作者:

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Nogo-66受体首先在神经元中发现。最近,它也在神经胶质细胞中得到证实。我们以前对Nogo-66受体在大鼠小脑中表达的研究发现,Nogo-66受体位于胶质细胞缝隙连接处。在这里,我们提出了我们的研究Nogo-66受体在大鼠垂体后叶,这是密集的垂体细胞,一种特殊类型的星形胶质细胞,并被称为是丰富的缝隙连接。我们能够证明与免疫组织化学和免疫电子显微镜丰富的Nogo-66受体免疫反应性垂体细胞之间的缝隙连接。这项研究,连同我们以前的一个,强烈表明,Nogo-66受体可能在调节差距连接的功能中发挥作用。
Nogo-66 receptor was first identified in neurons. Recently, it was demonstrated in glial cells as well. Our previous study on the expression of Nogo-66 receptor in the cerebellum of the rat surprisingly found its location at the glial gap junctions. Here, we present our study on Nogo-66 receptor in the rat posterior pituitary, which is densely packed with pituicytes, a special type of astrocyte, and is known to be rich in gap junctions. We were able to demonstrate with immunohistochemistry and immuno-electron microscopy abundant Nogo-66 receptor immunoreactive gap junctions between pituicytes. This study, together with our prior one, strongly suggests that the Nogo-66 receptor may play a role in regulating the function of the gap junctions.
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