Early and Late Neuronal Damage Following Cerebral Ischemia
Early and Late Neuronal Damage Following Cerebral Ischemia
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脑缺血后的早期和晚期神经元损伤
DOI：
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
K. Sano
中科院分区：
文献类型：
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作者：
T. Kirino;A. Tamura;K. Sano
海马体是大脑中最易受缺血影响的结构之一。人们普遍认为，在短短几分钟的脑缺血后，海马体最容易发生神经元死亡和“硬化”。然而，神经生理学家长期以来一直使用海马区切片的方法进行实验。他们知道，他们对主要从啮齿动物物种获得的海马体的体外切片准备令人惊讶地正常，并在数小时内保持正常(Lynch，1980)。在这个过程中，海马区组织在准备过程中不可避免地暴露在短暂的缺血中，直到它被切成切片。因此，神经生理学家的经验可能会证实，海马神经元，如果有的话，只有在极少数情况下，在短暂的缺血后才会迅速破坏。这些看似矛盾的观察结果可能会通过对海马区迟发性神经元死亡的认识来解决。大多数海马区CA1神经元在短暂缺血后死亡，但细胞解体发生得非常缓慢(Kirino，1982；Pulsinelli等人，1982)。几乎需要几天时间，才会出现明显的神经元死亡的形态迹象。随着大脑遭受更长时间的缺血，这种神经细胞变化在再循环后发展得更快(Kirino和Sano，1984a)。伊藤等人描述了神经元病理学的这种总体趋势。并称之为“成熟现象”(Ito等人，1975)。在啮齿动物的海马体中，迟发性神经元死亡最常见于脑缺血后存活时间超过几天的动物。另一方面，足够长的时间导致海马区广泛的急性细胞变化的缺血通常与动物的生存不相容。
The hippocampus is one of the most vulnerable structures in the brain to ischemia. It is been widely believed that the hippocampus is most easily subject to neuronal death and “sclerosis” following only a brief period of ischemia of merely a few minutes. However, neurophysiologists have long been using the hippocampal slice method for their experiments. They know that their in vitro slice preparation of the hippocampus obtained mainly from rodent species is surprisingly normal and remains normal for many hours (Lynch, 1980). In this procedure, hippocampal tissue is unavoidably exposed to brief ischemia during preparation until it is cut into slices. The experience of neurophysiologists may, therefore, confirm that hippocampal neurons, if any, are only on rare occasions destroyed rapidly following brief ischemia. These seemingly contradictory observations may be resolved by the recognition of delayed neuronal death in the hippocampus. Most of the hippocampal CA1 neurons die following brief ischemia, but cell disintegration takes place very slowly (Kirino, 1982; Pulsinelli et al., 1982). It takes almost days until overt morphological signs of neuronal death appear. As the brain is subjected to longer ischemia, this neuronal cell alteration develops faster following recirculation (Kirino and Sano, 1984a). This general tendency of neuronal pathology is describled by Ito et al. and called “maturation phenomenon” (Ito et al., 1975). In the rodent hippocampus, delayed neuronal death is most commonly encountered in animals which survive longer than a few days following ischemia. On the other hand, ischemia which is long enough to cause widespread acute cell change in the hippocampus is usually incompatible with animal survival.
通过穿通路径损伤改善海马结构缺血性神经元损伤的证据。
影响因子：
1.9
作者：
Wieloch,T;Lindvall,O;Blomqvist,P;Gage,FH
通讯作者：
Gage,FH