Long-term risk of mortality and other adverse outcomes after acute kidney injury: a systematic review and meta-analysis.
Long-term risk of mortality and other adverse outcomes after acute kidney injury: a systematic review and meta-analysis.
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DOI：
10.1053/j.ajkd.2008.11.034
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发表时间：
2009-06
期刊：
影响因子：
--
通讯作者：
Parikh CR
中科院分区：
文献类型：
--
作者：
Coca SG;Yusuf B;Shlipak MG;Garg AX;Parikh CR
急性肾损伤（阿基）在住院患者中很常见。阿基对长期结局的影响存在争议。系统回顾和荟萃分析.阿基患者。检索了1985年至2007年10月的MEDLINE和EMBASE数据库。纳入了描述出院存活患者阿基结局的原始研究。当参与者被随访< 6个月时，研究被排除在审查之外。阿基，定义为血清肌酐的急性变化或对肾脏替代治疗的急性需求。慢性肾病，心血管疾病，死亡率。审查了49项研究，共有47，017名参与者。其中15项研究报告了无阿基患者的长期数据。阿基幸存者的死亡率为8.9/100人-年，非阿基幸存者的死亡率为4.3/100人-年（RR 2.59，95% CI 1.97-3.42）。在进行多变量校正的6项研究中，阿基与死亡风险独立相关（校正RR 1.6-3.9），在2项研究中，AKI与心肌梗死相关（RR 2.05，95% CI 1.61-2.61）。阿基发作后CKD的发生率为7.8/100患者年，ESRD的发生率为4.9/100患者年。由于缺乏对适当的非AKI对照的随访，阿基后CKD和ESRD的相对风险无法达到。阿基的发生（定义为血清肌酐的急性变化）是住院患者长期不良结局风险升高的特征。
Acute kidney injury (AKI) is common in hospitalized patients. The impact of AKI on long-term outcomes is controversial. Systematic review and meta-analysis. Persons with AKI. MEDLINE and EMBASE databases were searched from 1985 through October 2007. Original studies describing outcomes of AKI for patients who survived hospital discharge were included. Studies were excluded from review when participants were followed for < 6 months. AKI, as defined by acute changes in serum creatinine or acute need for renal replacement therapy. CKD, cardiovascular disease, mortality. Forty nine studies that contained a total of 47,017 participants were reviewed. Fifteen of these studies reported long-term data for patients without AKI. The incidence rate of mortality was 8.9 per 100 person-years in survivors of AKI and was 4.3 per 100 patient-years in survivors without AKI (RR 2.59, 95% CI 1.97-3.42). AKI was associated independently with mortality risk in 6 of 6 studies that performed multivariate adjustment (adjusted RR 1.6-3.9) and it was associated with myocardial infarction in 2 of 2 studies (RR 2.05, 95% CI 1.61-2.61). The incidence rate of CKD after an episode of AKI was 7.8 per 100 patient years and the rate of ESRD was 4.9 per 100 patient-years. The relative risk for CKD and ESRD after AKI was unattainable due to lack of follow-up of appropriate non-AKI controls. The development of AKI, as defined by acute changes in serum creatinine characterizes hospitalized patients at elevated risk of long-term adverse outcomes.
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影响因子：
13.2
作者：
Abosaif, NY;Tolba, YA;El Nahas, AM
通讯作者：
El Nahas, AM
影响因子：
38.9
作者：
de Mendonça, A;Vincent, JL;Cantraine, F
通讯作者：
Cantraine, F
影响因子：
13.2
作者：
Coca, Steven G.;Peixoto, Aldo J.;Parikh, Chirag R.
通讯作者：
Parikh, Chirag R.
DOI：
10.1016/0197-2456(86)90046-2
发表时间：
1986-09-01
期刊：
CONTROLLED CLINICAL TRIALS
影响因子：
--
作者：
DERSIMONIAN, R;LAIRD, N
通讯作者：
LAIRD, N
影响因子：
13.2
作者：
Bagshaw, Sean M.;Mortis, Garth;Laupland, Kevin B.
通讯作者：
Laupland, Kevin B.