Oral squamous cell carcinoma-released brain-derived neurotrophic factor contributes to oral cancer pain by peripheral tropomyosin receptor kinase B activation.
Oral squamous cell carcinoma-released brain-derived neurotrophic factor contributes to oral cancer pain by peripheral tropomyosin receptor kinase B activation.
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DOI：
10.1097/j.pain.0000000000002382
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发表时间：
2022-03-01
期刊：
影响因子：
7.4
通讯作者：
Ruparel S
中科院分区：
文献类型：
--
作者：
Grayson M;Arris D;Wu P;Merlo J;Ibrahim T;Fang-Mei C;Valenzuela V;Ganatra S;Ruparel S
背景头颈癌 (HNC) 患者的生活质量众所周知，因为与其他癌症类型相比，头颈癌 (HNC) 患者的疼痛发生率更高[15; 43]。疼痛不仅是这些患者的首要症状，而且无法有效控制这种共病也是促使患者寻求初步治疗的原因[5； 16]。由于阿片类药物的不良反应，这些患者的选择有限，并且阿片类药物重新升级指数较高[34； 55]。 HNC 产生疼痛的机制尚不清楚；然而，据推测，疼痛的普遍性和严重程度较高是由于 HNC 肿瘤的异质特性和口面部组织的生理学所致 [21]。位于舌头或口底的口腔鳞状细胞癌 (OSCC) 疼痛最严重，即使肿瘤尺寸很小，也源自原发肿瘤发展部位 [8; 9； 15； 32]。这些患者经常报告自发性疼痛、咀嚼和吞咽时疼痛以及整个口面部区域的牵涉性疼痛[8； 9]。
BACKGROUNDQuality of life of head and neck cancer (HNC) patients is notoriously poor due to the greater prevalence of pain compared to other cancer types [15; 43]. Pain is not only the top ranked symptom for these patients, but unachievable management of this co-morbidity is what drives patients to seek initial treatment [5; 16]. These patients have limited options due to adverse effects of opioids and have higher opioid reescalation index [34; 55]. Mechanisms by which HNC produce pain in not yet clearly understood; however, it is speculated that the greater prevalence and severity of pain is due to the heterogenous properties of HNC tumors and the physiology of orofacial tissues [21]. Oral squamous cell carcinomas (OSCC) located in the tongue or floor of the mouth, report the highest pain severity, originating from site of primary tumor development even when the tumor is small in size [8; 9; 15; 32]. Spontaneous pain, pain while chewing and swallowing, and referred pain across the orofacial area is frequently reported by these patients [8; 9].
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影响因子：
64.5
作者：
Li L;Rutlin M;Abraira VE;Cassidy C;Kus L;Gong S;Jankowski MP;Luo W;Heintz N;Koerber HR;Woodbury CJ;Ginty DD
通讯作者：
Ginty DD
DOI：
10.1016/j.tripleo.2005.10.041
发表时间：
2006-07-01
期刊：
ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTOLOGY
影响因子：
--
作者：
Cuffari, Linneu;Tesseroli de Siqueira, Jose Tadeu;Rapaport, Abrao
通讯作者：
Rapaport, Abrao
DOI：
10.1016/j.ynpai.2017.04.001
发表时间：
2017-01-01
期刊：
Neurobiology of pain (Cambridge, Mass.)
影响因子：
--
作者：
Malcangio, Marzia
通讯作者：
Malcangio, Marzia
影响因子：
4
作者：
Connelly, ST;Schmidt, BL
通讯作者：
Schmidt, BL
影响因子：
15.3
作者：
Kerschensteiner, M;Gallmeier, E;Behrens, L;Leal, V V;Misgeld, T;Klinkert, W E;Kolbeck, R;Hoppe, E;Oropeza-Wekerle, R L;Bartke, I;Stadelmann, C;Lassmann, H;Wekerle, H;Hohlfeld, R
通讯作者：
Hohlfeld, R