Low dose parathyroid hormone maintains normal bone formation in adult male rats during rapid weight loss.
Low dose parathyroid hormone maintains normal bone formation in adult male rats during rapid weight loss.
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低剂量甲状旁腺激素可维持成年雄性大鼠体重快速减轻期间的正常骨形成。
DOI：
10.1016/j.bone.2010.12.034
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发表时间：
2011
期刊：
影响因子：
4.1
通讯作者：
Iwaniec,UrszulaT
中科院分区：
文献类型：
--
作者：
Turner,RussellT;Iwaniec,UrszulaT
持续的负能量平衡会导致骨质流失。目前尚不清楚是否可以预防与慢性能量负平衡相关的骨质流失。本研究的目的是评估间歇性低剂量甲状旁腺激素（PTH）治疗在严重能量限制期间维持正常骨形成的功效。将六个月大的雄性 Fisher 344 大鼠分为 4 个治疗组：(1) 基线组、(2) 随意 (ad lib) 喂养对照组、(3) 能量限制组（消耗 40% 随意摄入的热量）或 (4) 能量限制+低剂量 (1μg/kg/d) PTH。 14天的严格能量限制降低了体重和血清瘦素水平。与随意喂养的对照组相比，能量限制的大鼠在近端胫骨干骺端具有较低的松质骨形成、较高的破骨细胞周长/骨周长和较高的骨髓脂肪。此外，能量受限的大鼠胫腓骨骨连接处的骨膜骨形成率较低。对能量受限的大鼠施用 PTH 对体重减轻或破骨细胞周长/骨周长没有影响。相反，与能量限制的大鼠相比，用 PTH 治疗的能量限制的大鼠具有更高的松质骨和皮质骨形成率，并且与自由喂养的对照动物没有差异。此外，PTH 治疗维持了正常的骨髓肥胖。总之，成年雄性大鼠体重快速减轻伴随着骨形成减少和骨髓脂肪增加，而这些变化可以通过低剂量 PTH 治疗来预防。综上所述，结果表明，成年大鼠骨形成的能量消耗较低，PTH 治疗可有效防止与快速体重减轻相关的骨形成减少。
A persistent negative energy balance results in bone loss. It is not clear whether the bone loss associated with chronic negative energy balance can be prevented. The objective of this study was to assess the efficacy of intermittent low dose parathyroid hormone (PTH) treatment in maintaining normal bone formation during severe energy restriction. Six-month-old male Fisher 344 rats were divided into 4 treatment groups: (1) baseline, (2) ad libitum (ad lib)-fed control, (3) energy-restricted (to consume 40% ad lib caloric intake), or (4) energy-restricted+low dose (1μg/kg/d) PTH. Severe energy restriction for 14d decreased body weight and serum leptin levels. Compared to ad lib-fed controls, energy-restricted rats had lower cancellous bone formation, higher osteoclast perimeter/bone perimeter and higher bone marrow adiposity in the proximal tibial metaphysis. Also, the energy-restricted rats had a lower periosteal bone formation rate at the tibia–fibula synostosis. Administration of PTH to energy-restricted rats had no effect on weight loss or osteoclast perimeter/bone perimeter. In contrast, energy-restricted rats treated with PTH had higher rates of cancellous and cortical bone formation compared to energy-restricted rats, and did not differ from the ad lib-fed control animals. Furthermore, PTH treatment maintained normal bone marrow adiposity. In conclusion, rapid weight loss in adult male rats was accompanied by decreased bone formation and increased bone marrow adiposity and these changes were prevented by low dose PTH treatment. Taken together, the results suggest that the energy cost of bone formation in adult rats is low and PTH therapy is effective in preventing the reduced bone formation associated with rapid weight loss.
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通过抽吸、活检和组织形态学评估酒精中毒和肝硬化的骨髓细胞结构。
影响因子：
4.2
作者：
J. Batista;F. Santolaria;E. González‐Reimers;M. L. Brito;J. A. Jorge;L. Marsá;L. Hernández
通讯作者：
L. Hernández
人甲状旁腺激素（hPTH[1-34]）的间歇治疗增加了骨质减少大鼠的骨小梁体积，但没有增加连接性
影响因子：
6.2
作者：
N. Lane;J. Thompson;G. Strewler;J. Kinney
通讯作者：
J. Kinney
影响因子：
1.5
作者：
Vahle, JL;Sato, M;Nold, JB
通讯作者：
Nold, JB
甲状旁腺激素的程序化给药可增加后肢无负荷卵巢切除大鼠的骨形成并减少骨丢失。
DOI：
10.1210/endo.139.10.6227
发表时间：
1998
期刊：
Endocrinology.
影响因子：
--
作者：
Turner,RT;Evans,GL;Cavolina,JM;Halloran,B;Morey-Holton,E
通讯作者：
Morey-Holton,E
影响因子：
4.2
作者：
KWIECINSKI, GG;PETRIE, GI;DELUCA, HF
通讯作者：
DELUCA, HF