National Cancer Institute (NCI) Program for Natural Product Discovery: Exploring NCI-60 Screening Data of Natural Product Samples with Artificial Neural Networks.
National Cancer Institute (NCI) Program for Natural Product Discovery: Exploring NCI-60 Screening Data of Natural Product Samples with Artificial Neural Networks.
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DOI：
10.1021/acsomega.2c07416
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发表时间：
2023-03-14
期刊：
影响因子：
4.1
通讯作者：
O'Keefe, Barry R.
中科院分区：
文献类型：
--
作者：
Evans, Jason R.;Akee, Rhone K.;Chanana, Shaurya;McConachie, Grant D.;Thornburg, Christopher C.;Grkovic, Tanja;O'Keefe, Barry R.
National Cancer Institute (NCI) Program for Natural Product Discovery is a new initiative aimed at creating new technologies for natural product-based drug discovery. Here, we present the development of a neural network-based bioinformatics platform for visualization and analysis of natural product high-throughput screening data using the NCI’s 60 human tumor cell anticancer drug screen. We demonstrate how the tool enables visualization of similar patterns of response that can be parsed both chemically and taxonomically, grouping NCI-60 biological profiles in one easy-to-use bioinformatics interface.
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