NMDA Receptor-Mediated Motor Cortex Plasticity After 20 Hz Transcranial Alternating Current Stimulation.
NMDA Receptor-Mediated Motor Cortex Plasticity After 20 Hz Transcranial Alternating Current Stimulation.
复制标题
20 Hz 经颅交流电刺激后 NMDA 受体介导的运动皮层可塑性。
作者：
M. Wischnewski;M. Engelhardt;M. Salehinejad;D. Schutter;M. Kuo;M. Nitsche
经颅交流电刺激（tACS）已被证明可以调节初级运动皮层（M1）的神经振荡和兴奋性水平。这些影响可以持续一个多小时，并参与了n -甲基-d-天冬氨酸受体（NMDAR）介导的突触可塑性。然而，到目前为止，尚未探索tACS后效的皮层机制。在这里，我们对M1施加20 Hz β - tACS，同时参与者接受NMDAR拮抗剂右美沙芬或安慰剂，并探索对皮质β振荡和兴奋性的影响。当给予安慰剂药物时，β - tACS被发现增加皮层兴奋性和β振荡至少60分钟，而当给予右美沙芬时，这些作用完全消失。这些结果提供了第一个直接证据，证明tACS可以诱导nmdar介导的运动皮层可塑性，这有助于我们理解tACS对人类运动皮层生理学的影响。
Transcranial alternating current stimulation (tACS) has been shown to modulate neural oscillations and excitability levels in the primary motor cortex (M1). These effects can last for more than an hour and an involvement of N-methyl-d-aspartate receptor (NMDAR) mediated synaptic plasticity has been suggested. However, to date the cortical mechanisms underlying tACS after-effects have not been explored. Here, we applied 20 Hz beta tACS to M1 while participants received either the NMDAR antagonist dextromethorphan or a placebo and the effects on cortical beta oscillations and excitability were explored. When a placebo medication was administered, beta tACS was found to increase cortical excitability and beta oscillations for at least 60 min, whereas when dextromethorphan was administered, these effects were completely abolished. These results provide the first direct evidence that tACS can induce NMDAR-mediated plasticity in the motor cortex, which contributes to our understanding of tACS-induced influences on human motor cortex physiology.
对技巧的需求调节运动皮层的半球间抑制。
影响因子：
2.5
作者：
Wischnewski,Miles;Kowalski,GregM;Rink,Farrah;Belagaje,SamirR;Haut,MarcW;Hobbs,Gerald;Buetefisch,CathrinM
通讯作者：
Buetefisch,CathrinM
影响因子：
3.7
作者：
Zaehle T;Rach S;Herrmann CS
通讯作者：
Herrmann CS
影响因子：
9.8
作者：
Helfrich RF;Knepper H;Nolte G;Strüber D;Rach S;Herrmann CS;Schneider TR;Engel AK
通讯作者：
Engel AK