Mechanisms of Action and Efficacy of Hyaluronic Acid, Corticosteroids and Platelet-Rich Plasma in the Treatment of Temporomandibular Joint Osteoarthritis-A Systematic Review.
Mechanisms of Action and Efficacy of Hyaluronic Acid, Corticosteroids and Platelet-Rich Plasma in the Treatment of Temporomandibular Joint Osteoarthritis-A Systematic Review.
复制标题
透明质酸、皮质类固醇和富血小板血浆治疗颞下颌关节骨关节炎的作用机制和疗效的系统评价。
DOI：
10.3390/ijms22147405
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发表时间：
2021-07-09
影响因子：
5.6
通讯作者：
Pawlowska E
中科院分区：
文献类型：
--
作者：
Derwich M;Mitus-Kenig M;Pawlowska E
颞下颌关节骨关节炎（TMJOA）是一种低度炎症性疾病，病因复杂。本综述旨在介绍透明质酸（HA）、皮质类固醇（CS）和富血小板血浆（PRP）治疗TMJ OA的作用机制和疗效的当前知识状态。使用关键词：“（颞下颌关节）和（（骨关节炎）或（功能障碍）或（疾病）或（疼痛））和（（治疗）或（关节穿刺术）或（关节镜检查）或（注射））和（（透明质酸）或（皮质类固醇）或（富血小板血浆）"分析PubMed数据库。在筛选了363项结果后，16项研究被纳入本综述。关节穿刺术单独有效地减少疼痛和改善下颌功能的患者诊断为颞下颌关节OA。在关节穿刺术结束时额外注射HA（低分子量（LMW）HA或高分子量（HMW）HA或CS）不会改善最终临床结局。CS对关节软骨有一些负面影响。与额外PRP进样相关的结果不一致，并且相当可疑。进一步的研究应该是多中心的，基于更大的患者群体，应该回答是否其他方法的TMJ OA治疗比简单的关节穿刺术对患者更有益的问题。
Temporomandibular joint osteoarthritis (TMJ OA) is a low-inflammatory disorder with multifactorial etiology. The aim of this review was to present the current state of knowledge regarding the mechanisms of action and the efficacy of hyaluronic acid (HA), corticosteroids (CS) and platelet-rich plasma (PRP) in the treatment of TMJ OA.: The PubMed database was analyzed with the keywords: “(temporomandibular joint) AND ((osteoarthritis) OR (dysfunction) OR (disorders) OR (pain)) AND ((treatment) OR (arthrocentesis) OR (arthroscopy) OR (injection)) AND ((hyaluronic acid) OR (corticosteroid) OR (platelet rich plasma))”. After screening of 363 results, 16 studies were included in this review. Arthrocentesis alone effectively reduces pain and improves jaw function in patients diagnosed with TMJ OA. Additional injections of HA, either low-molecular-weight (LMW) HA or high-molecular-weight (HMW) HA, or CS at the end of the arthrocentesis do not improve the final clinical outcomes. CS present several negative effects on the articular cartilage. Results related to additional PRP injections are not consistent and are rather questionable. Further studies should be multicenter, based on a larger group of patients and should answer the question of whether other methods of TMJ OA treatment are more beneficial for the patients than simple arthrocentesis.
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影响因子：
0.6
作者：
Grambart, Sean T.
通讯作者：
Grambart, Sean T.
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