Tumor‐infiltrating dendritic cells in adenocarcinomas of the breast: a study of 143 neoplasms with a correlation to usual prognostic factors and to clinical outcome
Tumor‐infiltrating dendritic cells in adenocarcinomas of the breast: a study of 143 neoplasms with a correlation to usual prognostic factors and to clinical outcome
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乳腺腺癌中的肿瘤浸润树突状细胞：对 143 例肿瘤的研究，与常见预后因素和临床结果相关
DOI：
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发表时间：
1999
影响因子：
6.4
通讯作者：
D. Larsimont
中科院分区：
文献类型：
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作者：
L. Lespagnard;D. Gancberg;G. Rouas;G. Leclercq;N. de Saint;A. Di Leo;M. Piccart;A. Verhest;D. Larsimont
树突状细胞(DC)是最强大的抗原提呈细胞，能诱导抗原特异性免疫反应。DC对肿瘤的侵袭被认为反映了宿主免疫系统与肿瘤细胞之间的相互作用。肿瘤浸润性树突状细胞(TIDC)被认为进化为肿瘤抗原脉冲细胞，然后迁移到局部淋巴结，在那里它们激活抗肿瘤免疫反应。研究表明，在某些类型的肿瘤中，高TIDC密度与良好的预后相关，这为支持这一理论的间接临床证据提供了支持。在本研究中，我们使用抗S100蛋白抗体的免疫组织化学方法，评估了143例原发性乳腺癌中DC的存在。分析S100+TIDC的浸润度与常见预后因素及临床转归的关系。结果显示，42%的乳腺腺癌含有S100+TIDC。S100+TIDC的数目随肿瘤分级的不同而不同：GRIII和GT；GRII和GT；GRI。S100+tidc与肿瘤大小、淋巴结转移、雌孕激素受体状态和年龄有关。然而，S100+TIDC的存在，即使在最高密度，也与无转移生存期或总生存期无关。内部J·癌症(Pred.ONCOL.)84：309-314,1999。©1999 Wiley-Liss，Inc.
Dendritic cells (DC) are the most potent antigen‐presenting cells, and induce antigen‐specific immune responses. Infiltration of tumors by DC is thought to reflect the interaction between the host immune system and tumor cells. Tumor‐infiltrating DC (TIDC) are believed to evolve into tumor‐antigen pulsed cells and then to migrate to local lymph nodes, where they activate anti‐tumor immune responses. Indirect clinical evidence supporting this theory is provided by studies showing that high TIDC densities are associated with favorable prognosis in some tumor types. In the present study, we evaluated 143 primary breast adenocarcinomas for the presence of DC, using immunohistochemistry with the anti‐S100 protein antibody. We analyzed the relationship between the degree of infiltration by S100+ TIDC and the usual prognostic factors and clinical outcome. The results show that 42% of breast adenocarcinomas contain S100+ TIDC. The number of S100+ TIDC varies according to the grade of tumors as follows: GRIII > GRII > GRI. A relationship is also found between S100+ TIDC and tumor size, lymph‐node involvement, estrogen/progesterone receptor status and age. However, the presence of S100+ TIDC, even at the highest density, was not correlated with metastasis‐free survival or overall survival. Int. J. Cancer (Pred. Oncol.) 84:309–314, 1999. © 1999 Wiley‐Liss, Inc.
人阳光诱导的基底细胞癌相关树突状细胞缺乏 T 细胞共刺激分子，并且作为抗原呈递细胞受到损害。
DOI：
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发表时间：
1997
期刊：
The American journal of pathology
影响因子：
--
作者：
Nestle,FO;Burg,G;Fäh,J;Wrone-Smith,T;Nickoloff,BJ
通讯作者：
Nickoloff,BJ
影响因子：
3.7
作者：
Deng, Jingyu;Liang, Han;Liu, Xiangyu
通讯作者：
Liu, Xiangyu