Expression Quantitative Trait Loci for CARD8 Contributes to Risk of Two Infection-Related Cancers--Hepatocellular Carcinoma and Cervical Cancer.
Expression Quantitative Trait Loci for CARD8 Contributes to Risk of Two Infection-Related Cancers--Hepatocellular Carcinoma and Cervical Cancer.
复制标题
CARD8 的表达数量性状位点会增加两种感染相关癌症的风险——肝细胞癌和宫颈癌
DOI：
10.1371/journal.pone.0132352
复制
发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Li N
中科院分区：
文献类型：
--
作者：
Yin J;Wen J;Hang D;Han J;Jiang J;Song C;Liu Y;Liu J;Liu L;Zhu L;Chen J;Zhai X;Xie S;Hu Z;Shen H;Dai M;Li N
Caspase募集结构域家族成员8(CARD8)可以协调天然免疫和获得性免疫反应，并使细胞对凋亡敏感，这可能参与了病毒诱导的肝细胞癌和宫颈癌的发生。通过生物信息学分析，我们在一个新发现的长非编码RNA(LncRNA)中发现了几个单核苷酸多态(SNPs)，作为CARD8的表达数量性状基因座(EQTL)。因此，在这项研究中，我们假设LncRNA中的CARD8 eQTL SNPs可能影响肝癌和宫颈癌的风险。我们对1,300例乙肝病毒阳性的肝细胞癌患者和1,344例正常对照，以及1,486例宫颈癌患者和1,536例对照受试者进行了两项独立的病例对照研究，以检验CARD8基因eQTL SNP(Rs7248320)与肝癌和宫颈癌风险的关系。Rs7248320变异与患肝癌和宫颈癌的危险性显著相关[GG与AA/GA：调整优势比(OR)=1.2 8，95%可信区间(CI)=1.0 3~1.6 1，P=0.028；调整OR=1.3 4，95%CI=1.0 9~1.6 6，P=0.006]。此外，rs7248320对子宫颈癌风险的影响在绝经前妇女中更为突出。进一步的交互分析发现rs7248320与绝经状态对宫颈癌风险有显著的乘性交互作用(P=0.018)。这些发现提示CARD8 eQTL SNP可能是病毒相关性肝癌和宫颈癌的易感标志物。
Caspase recruitment domain family, member 8 (CARD8) can coordinate innate and adaptive immune responses and sensitize cells to apoptosis, which may participate in tumorigenesis of virus-induced hepatocellular carcinoma (HCC) and cervical cancer. By bioinformatics analyses, we identified several single nucleotide polymorphisms (SNPs) within a new identified long non-coding RNA (lncRNA) as expression quantitative trait loci (eQTLs) for CARD8. In this study, we therefore hypothesized that CARD8 eQTLs SNPs within lncRNA may influence the risk of HCC and cervical cancer. We performed two independent case-control studies of 1,300 cases with HBV-positive HCC and 1,344 normal controls, together with 1,486 cervical cancer patients and 1,536 control subjects to test the association between eQTLs SNP (rs7248320) for CARD8 and the risk of HCC and cervical cancer. The variant genotype of rs7248320 was significantly associated with increased risk of HCC and cervical cancer [GG vs. AA/GA: adjusted odds ratio (OR) = 1.28, 95% confidence interval (CI) = 1.03–1.61, P = 0.028 for HCC; adjusted OR = 1.34, 95% CI = 1.09–1.66, P = 0.006 for cervical cancer]. Moreover, the effect of rs7248320 on cervical cancer risk was more prominent in premenopausal women. Further interactive analysis detected a significantly multiplicative interaction between rs7248320 and menopausal status on cervical cancer risk (P = 0.018). These findings suggest that CARD8 eQTLs SNP may serve as a susceptibility marker for virus-related HCC and cervical cancer.
登录
查看更多内容
影响因子：
8
作者：
Braconi, C.;Kogure, T.;Valeri, N.;Huang, N.;Nuovo, G.;Costinean, S.;Negrini, M.;Miotto, E.;Croce, C. M.;Patel, T.
通讯作者：
Patel, T.
影响因子：
7
作者：
Boyle AP;Hong EL;Hariharan M;Cheng Y;Schaub MA;Kasowski M;Karczewski KJ;Park J;Hitz BC;Weng S;Cherry JM;Snyder M
通讯作者：
Snyder M
影响因子：
--
作者：
Verma, Deepti;Lerm, Maria;Sarndahl, Eva
通讯作者：
Sarndahl, Eva
DOI：
10.1007/978-1-4614-0899-4_15
发表时间：
2012-01-01
期刊：
NOTCH SIGNALING IN EMBRYOLOGY AND CANCER
影响因子：
--
作者：
Dang, Thao P.
通讯作者：
Dang, Thao P.
影响因子：
--
作者：
Gaballah, Hanaa Hibishy;Zakaria, Soha Said;Ismail, Saber Abdelrahman
通讯作者：
Ismail, Saber Abdelrahman