Tobacco Smoke and CYP1A2 Activity in a US Population with Normal Liver Enzyme Levels.
Tobacco Smoke and CYP1A2 Activity in a US Population with Normal Liver Enzyme Levels.
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DOI：
10.3390/ijerph18052225
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发表时间：
2021-02-24
影响因子：
--
通讯作者：
Wu T
中科院分区：
文献类型：
--
作者：
Garduno A;Wu T
非酒精性脂肪性肝病（NAFLD）在30%的美国成年人中很常见。与从不吸烟者相比，曾经和现在的吸烟者患NAFLD的风险更高。尿液咖啡因代谢物与咖啡因摄入量的比值，即尿液咖啡因代谢物指数，此前已被用作CYP1A2活性的替代指标，CYP1A2是主要的肝脏代谢酶之一。CYP1A2活性与NAFLD进展相关。据我们所知，没有研究调查了肝酶、吸烟强度和二手烟（SES）与CYP1A2活性（使用咖啡因代谢物指数）在吸烟状况中的关系。我们分析了2009-2010年全国健康与营养检查调查（NHANES）的全国代表性样本。有趣的是，即使在正常范围内，几种肝酶也与咖啡因代谢物指数相关，而且这些关联的模式因吸烟状况而异。例如，在正常范围内，从不吸烟者的天冬氨酸转氨酶（AST）和当前吸烟者的胆红素与1-甲基尿酸和5-乙酰氨基-6-氨基-3-甲基尿嘧啶（URXAMU）呈负相关。此外，我们观察到一个共同的模式：在所有吸烟状态中，较高的AST/丙氨酸转氨酶（AST/ALT）与1-甲基尿酸和URXAMU相关。此外，在当前吸烟者中，终生吸烟强度的增加与咖啡因代谢物指数的降低有关，但在从不吸烟者中，通过SES水平测量的急性香烟暴露与咖啡因代谢物指数的增加有关。综上所述，常用的肝酶检测即使在正常范围内也能反映CYP1A2的活性，但这些酶的选择取决于吸烟状况；吸烟与CYP1A2活性之间的联系不仅取决于吸烟的强度，还取决于吸烟的持续时间。
Non-alcoholic fatty liver disease (NAFLD) is common among 30% of American adults. Former and current smokers are at higher risk for NAFLD compared to never smokers. The ratio of urine caffeine metabolites to caffeine intake—namely, urine caffeine metabolite indices—has previously been used as a proxy for CYP1A2 activity, which is one of the main liver metabolizing enzymes. CYP1A2 activity is associated with NAFLD progression. No studies to our knowledge have examined the associations of liver enzymes, smoking intensity, and secondhand smoke (SES) with CYP1A2 activity (using caffeine metabolite indices) across smoking status. We analyzed national representative samples from the 2009–2010 National Health and Nutrition Examination Survey (NHANES). Interestingly, even within a normal range, several liver enzymes were associated with caffeine metabolite indices, and patterns of many of these associations varied by smoking status. For instance, within a normal range, aspartate aminotransferase (AST) in never smokers and bilirubin in current smokers were inversely associated with 1-methyluric acid and 5-acetylamino-6-amino-3-methyluracil (URXAMU). Furthermore, we observed a common pattern: across all smoking statuses, higher AST/alanine aminotransferase (AST/ALT) was associated with 1-methyluric acid and URXAMU. Moreover, in current smokers, increased lifelong smoking intensity was associated with reduced caffeine metabolite indices, but acute cigarette exposure as measured by SES levels was associated with increased caffeine metabolite indices among never smokers. In summary, commonly used liver enzyme tests can reflect the CYP1A2 activity even within a normal range, but the selection of these enzymes depends on the smoking status; the associations between smoking and the CYP1A2 activity not only depend on the intensity but also the duration of tobacco exposure.
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影响因子：
29.4
作者：
Cotter, Thomas G.;Rinella, Mary
通讯作者：
Rinella, Mary
影响因子：
4.2
作者：
Blanton, Cynthia A.;Moshfegh, Alanna J.;Kretsch, Mary J.
通讯作者：
Kretsch, Mary J.
DOI：
10.1002/bms.1200200503
发表时间：
1991-05-01
期刊：
BIOLOGICAL MASS SPECTROMETRY
影响因子：
--
作者：
JACOB, P;YU, L;BENOWITZ, NL
通讯作者：
BENOWITZ, NL
影响因子：
7.1
作者：
Rodenburg, Eline M.;Eijgelsheim, Mark;Visser, Loes E.
通讯作者：
Visser, Loes E.
影响因子：
13.5
作者：
Marrero, JA;Fontana, RJ;Lok, AS
通讯作者：
Lok, AS