Histone Demethylases Coordinate the Antagonistic Interaction Between Abscisic Acid and Brassinosteroid Signaling in Arabidopsis.
Histone Demethylases Coordinate the Antagonistic Interaction Between Abscisic Acid and Brassinosteroid Signaling in Arabidopsis.
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DOI：
10.3389/fpls.2020.596835
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发表时间：
2020
影响因子：
5.6
通讯作者：
Ito T
中科院分区：
文献类型：
--
作者：
Wu J;Yan M;Zhang D;Zhou D;Yamaguchi N;Ito T
脱落酸（阿坝）与油菜素内酯（BR）相互拮抗，调控植物生长发育。对环境线索的反应包括通过基因表达的表观遗传调节的激素控制。然而，ABA-BR串扰的细节在很大程度上仍然未知。在这里，我们表明，JUMONJI-C结构域含有组蛋白去甲基化酶（JMJ）协调阿坝和BR信号通路之间的拮抗作用在萌发后阶段在拟南芥。BR通过抑制JMJ 30阻断ABA介导的幼苗停滞。JMJ从BRASSINAZOLE RESISTANT 1（BZR 1）基因座上去除抑制性组蛋白标记，以激活其平衡阿坝和BR信号通路。JMJ和BZR 1共同调节编码三种膜蛋白的基因，一种液泡形态的调节因子和两种脂质转移蛋白，每种蛋白在转运中发挥不同的作用。BZR 1还在JMJ独立途径中调节刺激相关的靶基因。我们的研究结果表明，组蛋白去甲基化酶整合阿坝和BR信号，导致萌发后的生长程序的变化。
Abscisic acid (ABA) interacts antagonistically with brassinosteroids (BRs) to control plant growth and development in response to stress. The response to environmental cues includes hormonal control via epigenetic regulation of gene expression. However, the details of the ABA–BR crosstalk remain largely unknown. Here, we show that JUMONJI-C domain containing histone demethylases (JMJs) coordinate the antagonistic interaction between ABA and BR signaling pathways during the post-germination stage in Arabidopsis. BR blocks ABA-mediated seedling arrest through repression of JMJ30. JMJs remove the repressive histone marks from the BRASSINAZOLE RESISTANT1 (BZR1) locus for its activation to balance ABA and BR signaling pathways. JMJs and BZR1 co-regulate genes encoding three membrane proteins, a regulator of vacuole morphology, and two lipid-transfer proteins, each of which play a different role in transport. BZR1 also regulates stimuli-related target genes in a JMJ-independent pathway. Our findings suggest that the histone demethylases integrate ABA and BR signals, leading to changes in growth program after germination.
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影响因子：
3.1
作者：
Lee, Dong Ju;Park, Jin-Young;Kim, Jungmook
通讯作者：
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