No Reduction in the 226-Hz Probe Tone Acoustic Reflex Amplitude Following Severe Inner Hair Cell Loss in Chinchillas.
No Reduction in the 226-Hz Probe Tone Acoustic Reflex Amplitude Following Severe Inner Hair Cell Loss in Chinchillas.
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龙猫内毛细胞严重损失后，226 Hz 探针音声反射幅度没有减少。
DOI：
10.1007/s10162-022-00861-3
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Lobarinas,Edward
中科院分区：
文献类型：
--
作者：
Trevino,Monica;Escabi,Celia;Swanner,Hannah;Pawlowski,Karen;Lobarinas,Edward
中耳声反射（AR）和内毛细胞（IHC）损失之间的关系目前尚不清楚。考虑到IHC被认为将几乎所有的声学信息传递到中枢听觉神经系统，已经假设IHC的丧失将显著影响AR。为了评估这种关系，我们评估了卡铂治疗前后毛丝鼠AR的存在和幅度，卡铂是一种可靠且选择性地破坏该物种IHC的抗癌药物。基线测量的听力灵敏度，包括听觉脑干反应（ABR）阈值和畸变产物耳声发射（DPOAE），进行了评估，然后重新评估后卡铂治疗。卡铂治疗后ABR阈值和DPOAE未发生变化或略有升高;结果与已发表的报告一致。我们的主要假设是，IHC的损失将取消反射或显着降低其幅度。与我们的假设相反，同侧226-Hz AR在卡铂治疗后继续可靠地引起。死后组织学分析证实了显著的IHC损失（65- 85%），但没有可测量的外毛细胞（OHC）损失。考虑到单独的IHC损失不会显著降低226-Hz AR，我们的结果表明几乎不需要IHC来维持226-Hz AR反应。这些结果表明，需要进行额外的研究来更好地了解免疫组织化学在反射弧中的作用，为进一步研究反射途径提供机会，并可能改变我们使用临床AR作为免疫组织化学功能障碍（包括与免疫组织化学相关的功能障碍）的潜在诊断工具的方式。突触病。
The relationship between the middle ear acoustic reflex (AR) and inner hair cell (IHC) loss is currently unknown. Given that IHC are believed to convey nearly all acoustic information to the central auditory nervous system, it has been assumed that loss of IHC would significantly impact the AR. To evaluate this relationship, we assessed the presence and amplitude of the AR in chinchillas before and after treatment with carboplatin, an anticancer drug that reliably and selectively destroys IHC in this species. Baseline measures of hearing sensitivity, including auditory brainstem response (ABR) thresholds and distortion product otoacoustic emissions (DPOAE), were assessed and then re-evaluated following carboplatin treatment. Post-carboplatin ABR thresholds and DPOAE were found to be unchanged or slightly elevated; results were consistent with published reports. Our main hypothesis was that loss of IHC would abolish the reflex or significantly reduce its amplitude. Contrary to our hypothesis, the ipsilateral 226-Hz AR continued to be reliably elicited following carboplatin treatment. Post-mortem histological analysis confirmed significant IHC loss (65–85 %), but no measurable loss of outer hair cells (OHCs). Given that loss of IHC alone does not significantly reduce the 226-Hz AR, our results suggest that few IHC are needed to maintain the 226-Hz AR response. These results suggest additional studies are needed to better understand the role of IHC in the reflex arc, present opportunities to further study the reflex pathway, and could change how we use the clinical AR as a potential diagnostic tool for IHC dysfunction, including those related to IHC synaptopathy.
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DOI：
10.1037//0278-6133.9.4.435
发表时间：
1990
期刊：
Health psychology : official journal of the Division of Health Psychology, American Psychological Association
影响因子：
--
作者：
R. Klesges;L. Eck;C. L. Hanson;Haddock Ck;L. Klesges
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影响因子：
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影响因子：
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DOI：
--
发表时间：
1985
期刊：
The Journal of the Royal College of General Practitioners
影响因子：
--
作者：
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通讯作者：
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影响因子：
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