Induction of Accelerated Aging in a Mouse Model.
Induction of Accelerated Aging in a Mouse Model.
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小鼠模型中加速衰老的诱导
DOI：
10.3390/cells11091418
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发表时间：
2022-04-22
期刊：
影响因子：
6
通讯作者：
Huang, Yan
中科院分区：
文献类型：
--
作者：
Cai, Nanshuo;Wu, Yifan;Huang, Yan
随着全球老年人口的增加，提高各种老年相关疾病的治疗水平，延长健康寿命已成为当前最重要的医学问题。为了了解衰老和衰老相关疾病的发育机制，动物模型是开展相关研究的必要条件。其中，小鼠因其在遗传背景和生理结构上与人类高度相似，且寿命短，易于繁殖，成为衰老相关研究最常用的模型动物之一。本文将对近年来常见和新兴的加速衰老及相关慢性疾病的小鼠模型进行综述，以期为今后在基础和转化研究中的应用提供参考。
With the global increase of the elderly population, the improvement of the treatment for various aging-related diseases and the extension of a healthy lifespan have become some of the most important current medical issues. In order to understand the developmental mechanisms of aging and aging-related disorders, animal models are essential to conduct relevant studies. Among them, mice have become one of the most prevalently used model animals for aging-related studies due to their high similarity to humans in terms of genetic background and physiological structure, as well as their short lifespan and ease of reproduction. This review will discuss some of the common and emerging mouse models of accelerated aging and related chronic diseases in recent years, with the aim of serving as a reference for future application in fundamental and translational research.
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影响因子：
4.3
作者：
Brennan TA;Egan KP;Lindborg CM;Chen Q;Sweetwyne MT;Hankenson KD;Xie SX;Johnson FB;Pignolo RJ
通讯作者：
Pignolo RJ
影响因子：
64.8
作者：
通讯作者：
--
DOI：
10.1007/978-1-4939-8570-8_19
发表时间：
2018
期刊：
Methods in molecular biology (Clifton, N.J.)
影响因子：
--
作者：
Stober VP;Garantziotis S
通讯作者：
Garantziotis S
影响因子：
4.5
作者：
Alvarez-García, O;Vega-Naredo, I;Coto-Montes, A
通讯作者：
Coto-Montes, A
影响因子：
4.5
作者：
Campos, Fabian;Abrigo, Johanna;Cabello-Verrugio, Claudio
通讯作者：
Cabello-Verrugio, Claudio