Preparing an oncolytic poliovirus recombinant for clinical application against glioblastoma multiforme.
Preparing an oncolytic poliovirus recombinant for clinical application against glioblastoma multiforme.
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DOI：
10.1016/j.cytogfr.2010.02.005
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发表时间：
2010-04
影响因子：
13
通讯作者：
Gromeier, Matthias
中科院分区：
文献类型：
--
作者：
Goetz, Christian;Gromeier, Matthias
PVS-RIPO is a genetically recombinant, non-pathogenic poliovirus chimera with a tumor-specific conditional replication phenotype. Consisting of the genome of the live attenuated poliovirus type 1 (Sabin) vaccine with its cognate IRES element replaced with that of human rhinovirus type 2, PVS-RIPO displays an inability to translate its genome in untransformed neuronal cells, but effectively does so in cells originating from primary tumors in the central nervous system or other cancers. Hence, PVS-RIPO unleashes potent cytotoxic effects on infected cancer cells and produces sustained anti-tumoral responses in animal tumor models. PVS-RIPO presents a novel approach to the treatment of patients with glioblastoma multiforme, based on conditions favoring an unconventional viral translation initiation mechanism in cancerous cells. In this review, we summarize advances in the understanding of major molecular determinants of PVS-RIPO oncolytic efficacy and safety and discuss their implications for upcoming clinical investigations.
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DOI：
10.1038/mt.2008.184
发表时间：
2008-11
期刊：
Molecular therapy : the journal of the American Society of Gene Therapy
影响因子：
--
作者：
Dobrikova EY;Broadt T;Poiley-Nelson J;Yang X;Soman G;Giardina S;Harris R;Gromeier M
通讯作者：
Gromeier M
影响因子：
5.4
作者：
Gromeier, M;Bossert, B;Wimmer, E
通讯作者：
Wimmer, E
影响因子：
12.4
作者：
Grandi, P;Wang, S;Breakefield, XO
通讯作者：
Breakefield, XO
影响因子：
50.3
作者：
Balachandran, S;Barber, GN
通讯作者：
Barber, GN
DOI：
10.1073/pnas.97.12.6803
发表时间：
2000-06-06
影响因子：
11.1
作者：
Gromeier, M;Lachmann, S;Wimmer, E
通讯作者：
Wimmer, E