Butenolide, a Marine-Derived Broad-Spectrum Antibiofilm Agent Against Both Gram-Positive and Gram-Negative Pathogenic Bacteria
Butenolide, a Marine-Derived Broad-Spectrum Antibiofilm Agent Against Both Gram-Positive and Gram-Negative Pathogenic Bacteria
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丁烯内酯，一种海洋源性广谱抗菌膜剂，可对抗革兰氏阳性和革兰氏阴性致病菌
DOI：
10.1007/s10126-018-9861-1
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发表时间：
2019-01
影响因子：
3
通讯作者：
Xu Ying
中科院分区：
文献类型：
--
作者：
Yin Qi;Liang Jinyou;Zhang Weipeng;Zhang Lv;Hu Zhang-Li;Zhang Yu;Xu Ying
细菌生物被膜可引起医院内反复感染和植入物继发感染，在临床治疗中极大地促进了病原菌耐药性的发展。丁烯内酯是从海洋链霉菌中提取的一种有效的抗大污染化合物，但其抗生物被膜的效果仍未得到很大的研究。本研究利用革兰氏阳性和革兰氏阴性致病模式菌所形成的生物膜，对丁烯内酯的抗生物膜活性进行了研究。以4株大肠埃希菌、铜绿假单胞菌和耐甲氧西林金黄色葡萄球菌(MRSA)为靶标，研究了丁烯内酯对细菌生长、抑制生物膜形成和消除成熟生物膜的影响。此外，还考察了丁烯内酯与四环素的协同作用。丁烯内酯不仅有效地抑制了生物膜的形成，而且还能有效地消除受试菌的预先形成的生物膜。分数抑菌浓度指数(FICI)表明丁烯内酯是一种潜在的四环素增强剂。大肠埃希菌、铜绿假单胞菌和耐甲氧西林金黄色葡萄球菌。这些结果表明，丁烯内酯作为一种有效的抗生物被膜药物在未来的临床治疗中可能具有控制和预防生物被膜相关感染的巨大潜力。
Bacterial biofilm can cause nosocomial recurrent infections and implanted device secondary infections in patients and strongly promotes development of pathogenic drug resistance in clinical treatments. Butenolide is an effective anti-macrofouling compound derived from a marineStreptomycessp., but its antibiofilm efficacy remains largely unexplored. In the present study, the antibiofilm activities of butenolide were examined using biofilms formed by both Gram-positive and Gram-negative pathogenic model species. FourEscherichia colistrains,Pseudomonas aeruginosa, and methicillin-resistantStaphylococcus aureus(MRSA) were used as targets in antibiofilm assays that examined the effects of butenolide, including the following: (i) on bacterial growth; (ii) in inhibiting biofilm formation and eradicating mature biofilm; (iii) on biofilm structures. In addition, the synergistic effect between butenolide with tetracycline was also examined. Butenolide not only effectively inhibited the biofilm formation but also eradicated pre-formed biofilms of tested bacteria. Fractional inhibitory concentration index (FICI) indicated that butenolide was a potential tetracycline enhancer againstE. coli,P. aeruginosa, and MRSA. These results indicated that butenolide may hold a great potential as an effective antibiofilm agent to control and prevent biofilm-associated infections in future clinical treatments.
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影响因子：
5
作者：
Ren, D;Bedzyk, LA;Wood, TK
通讯作者：
Wood, TK
影响因子：
5.2
作者：
Luo Y;McLean DT;Linden GJ;McAuley DF;McMullan R;Lundy FT
通讯作者：
Lundy FT
影响因子：
4.9
作者：
Nair, Sandhya;Desai, Srividya;Sharma, Umender
通讯作者：
Sharma, Umender
影响因子：
4.6
作者：
Bren A;Park JO;Towbin BD;Dekel E;Rabinowitz JD;Alon U
通讯作者：
Alon U
影响因子：
4.9
作者：
Kuehl, Richard;Al-Bataineh, Sameer;Landmann, Regine
通讯作者：
Landmann, Regine