Maillard reaction between oligopeptides and reducing sugar at body temperature: The putative anti-glycation agents.
Maillard reaction between oligopeptides and reducing sugar at body temperature: The putative anti-glycation agents.
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DOI：
10.3389/fnut.2022.1062777
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发表时间：
2022
影响因子：
5
通讯作者：
Wang, Puzhi
中科院分区：
文献类型：
--
作者：
Wang, Qiang;Xiang, Xiaofeng;Xie, Yuejie;Wang, Kai;Wang, Cao;Nie, Xuyuan;Wang, Puzhi
2型糖尿病（T2DM）是最常见的慢性多因素疾病之一，与血液中葡萄糖浓度升高有关。因此，使用降血药显然是一种有前途的方法，它可以抑制所评估的血糖，从而治愈 T2DM 和其他并发症。在这项研究中，我们通过在37°C和pH 7.4下与葡萄糖、果糖和蔗糖反应来模拟它们在生理条件下的反应，评估了多种氨基酸（丙氨酸和组氨酸）、二肽（肌肽和α-丙氨酸-L-组氨酸）和三肽（谷胱甘肽）的降血糖作用。通过测量21天储存过程中反应物的减少和美拉德反应产物的形成，我们发现肌肽的降糖效果优于同类产品。肌肽中的组氨酸残基可能有助于其降血糖作用，而β-氨基酸β-丙氨酸残基可以通过在储存过程中保持其化学稳定性来促进肌肽的降血糖作用。这些结果可能为生物活性肽肌肽作为天然降血糖剂控制 T2DM 的应用开辟新途径。
Type 2 Diabetes mellitus (T2DM) is one of the most common chronic multifactorial diseases, which is associated with the increased concentration of glucose in the blood. Therefore, the utilization of blood lowering agents is clearly a promising approach which can lead to a suppression of the evaluated blood glucose, and thus curing T2DM and other complication. In this study, we evaluated the glucose lowering effect of a varieties of amino acids (alanine and histidine), dipeptides (carnosine and α-alanine-L-histidine), and tripeptide (glutathione) by reacting with glucose, fructose, and sucrose under 37°C and pH 7.4 to mimic their reaction in physiological condition. By measuring the reduction of reactants and the formation of Maillard reaction products over the course of 21 days’ storage, we found that the glucose lowering effect of carnosine was better than the counterparts. The histidine residue in carnosine may contribute to its glucose lowing effect while β-amino acid β-alanine residue could facilitate the glucose lowering effect of carnosine by maintaining its chemical stability during the storage. These results may open up new avenues for the applications of bioactive peptide carnosine as a natural blood sugar lowering agent to control T2DM.
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DOI：
10.1007/s13300-021-01058-2
发表时间：
2021-07
期刊：
Diabetes therapy : research, treatment and education of diabetes and related disorders
影响因子：
--
作者：
Tarry-Adkins JL;Grant ID;Ozanne SE;Reynolds RM;Aiken CE
通讯作者：
Aiken CE
影响因子：
5
作者：
Chen, Keyu;Gao, Zezheng;Ding, Qiyou;Tang, Cheng;Zhang, Haiyu;Zhai, Tiangang;Xie, Weinan;Jin, Zishan;Zhao, Linhua;Liu, Wenke
通讯作者：
Liu, Wenke
影响因子：
4
作者：
Kuerban, Abudukadeer;Al-Malki, Abdulrahman L.;Salama Moselhy, Said
通讯作者：
Salama Moselhy, Said
影响因子：
5
作者：
Chen, Ziting;Tan, Jiangying;Qin, Jiabin;Feng, Nianjie;Liu, Qianting;Zhang, Chan;Wu, Qian
通讯作者：
Wu, Qian
影响因子：
3.1
作者：
MORI, N;BAI, Y;MANNING, JM
通讯作者：
MANNING, JM