Effect of natural polyphenols in Chinese herbal medicine on obesity and diabetes: Interactions among gut microbiota, metabolism, and immunity.
Effect of natural polyphenols in Chinese herbal medicine on obesity and diabetes: Interactions among gut microbiota, metabolism, and immunity.
复制标题
中草药中天然多酚对肥胖和糖尿病的影响：肠道菌群、代谢和免疫之间的相互作用。
DOI：
10.3389/fnut.2022.962720
复制
发表时间：
2022
影响因子：
5
通讯作者：
Liu, Wenke
中科院分区：
文献类型：
--
作者：
Chen, Keyu;Gao, Zezheng;Ding, Qiyou;Tang, Cheng;Zhang, Haiyu;Zhai, Tiangang;Xie, Weinan;Jin, Zishan;Zhao, Linhua;Liu, Wenke
关键词：
随着全球的流行，以肥胖和2型糖尿病(T2 DM)为代表的代谢性疾病给人类健康和医疗费用带来了巨大的负担。据估计，近40年来肥胖人口翻了一番，未来25年糖尿病人口将增加1.5倍，这促使人们追求经济有效的预防和治疗方法。天然多酚类化合物作为一类天然生物活性物质，在缓解肥胖和2型糖尿病等方面具有潜在的有益作用。本文对肥胖和2型糖尿病中肠道微生物紊乱、代谢紊乱和免疫失衡的网络相互作用机制进行了研究，并系统总结了其在肥胖和T2 DM治疗中的多重靶点，包括丰富有益的肠道微生物区系(双歧杆菌属、阿克曼属和乳杆菌)和上调肠道微生物区系衍生代谢物[短链脂肪酸(SCFAs)]和胆汁酸(BAS)的水平。此外，我们还探讨了它们对宿主糖脂代谢、AMPK途径的影响，以及通过抑制促炎免疫细胞(M1样MϕS、Th1和Th17细胞)、增殖、募集、分化和功能以及相关细胞因子(肿瘤坏死因子-α、IL-1β、IL-6、IL-17和单核细胞趋化蛋白-1)对免疫调节的影响。希望为促进天然多酚在肥胖和2型糖尿病治疗中的临床应用提供依据。
With global prevalence, metabolic diseases, represented by obesity and type 2 diabetes mellitus (T2DM), have a huge burden on human health and medical expenses. It is estimated that obese population has doubled in recent 40 years, and population with diabetes will increase 1.5 times in next 25 years, which has inspired the pursuit of economical and effective prevention and treatment methods. Natural polyphenols are emerging as a class of natural bioactive compounds with potential beneficial effects on the alleviation of obesity and T2DM. In this review, we investigated the network interaction mechanism of “gut microbial disturbance, metabolic disorder, and immune imbalance” in both obesity and T2DM and systemically summarized their multiple targets in the treatment of obesity and T2DM, including enrichment of the beneficial gut microbiota (genera Bifidobacterium, Akkermansia, and Lactobacillus) and upregulation of the levels of gut microbiota-derived metabolites [short-chain fatty acids (SCFAs)] and bile acids (BAs). Moreover, we explored their effect on host glucolipid metabolism, the AMPK pathway, and immune modulation via the inhibition of pro-inflammatory immune cells (M1-like Mϕs, Th1, and Th17 cells); proliferation, recruitment, differentiation, and function; and related cytokines (TNF-α, IL-1β, IL-6, IL-17, and MCP-1). We hope to provide evidence to promote the clinical application of natural polyphenols in the management of obesity and T2DM.
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影响因子：
11.4
作者：
Cremonini E;Daveri E;Iglesias DE;Kang J;Wang Z;Gray R;Mastaloudis A;Kay CD;Hester SN;Wood SM;Fraga CG;Oteiza PI
通讯作者：
Oteiza PI
DOI：
10.3390/molecules27082498
发表时间：
2022-04-13
期刊：
Molecules (Basel, Switzerland)
影响因子：
--
作者：
通讯作者：
--
影响因子：
5.1
作者：
Derochette, Sandrine;Franck, Thierry;Serteyn, Didier
通讯作者：
Serteyn, Didier
影响因子：
8.8
作者：
Castro-Lopez, Cecilia;Ventura-Sobrevilla, Janeth M.;Martinez-Avila, Guillermo C. G.
通讯作者：
Martinez-Avila, Guillermo C. G.
影响因子：
7.2
作者：
Adibian, Mahsa;Hodaei, Homa;Hedayati, Mehdi
通讯作者：
Hedayati, Mehdi