Pharmacological Properties of Chalcones: A Review of Preclinical Including Molecular Mechanisms and Clinical Evidence.
Pharmacological Properties of Chalcones: A Review of Preclinical Including Molecular Mechanisms and Clinical Evidence.
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DOI：
10.3389/fphar.2020.592654
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发表时间：
2020
影响因子：
5.6
通讯作者：
Les F
中科院分区：
文献类型：
--
作者：
Salehi B;Quispe C;Chamkhi I;El Omari N;Balahbib A;Sharifi-Rad J;Bouyahya A;Akram M;Iqbal M;Docea AO;Caruntu C;Leyva-Gómez G;Dey A;Martorell M;Calina D;López V;Les F
查尔酮是主要的生物活性类黄酮之一，具有治疗潜力，与一系列临床前和临床研究调查的一系列生物活性有关。在本文中，搜索不同的科学数据库以检索描述查尔酮及其衍生物的生物活性的研究。本文综述了查尔酮及其衍生物的临床前研究，阐述了查尔酮类化合物在抗糖尿病、抗癌、抗炎、抗菌、抗氧化、抗寄生虫、精神活性和神经保护等方面的重要作用。此外，临床试验显示，它们用于治疗慢性静脉功能不全、皮肤病和癌症。查尔酮及其衍生物的生物利用度研究表明，在营养食品和医药应用方面可能存在障碍和改善。查尔酮作用的多方面和复杂的潜在机制表明，它们有能力调节一些癌细胞系，抑制一些病理微生物和寄生虫，并控制一些与疾病修饰相关的信号分子和级联反应。对查尔酮的临床研究表明，除了减少临床症状和体征外，查尔酮一般没有副作用，具有良好的生物利用度。需要进一步的研究来阐明它们的结构活性、毒性问题、作用模式的细胞基础以及与其他分子的相互作用。
Chalcones are among the leading bioactive flavonoids with a therapeutic potential implicated to an array of bioactivities investigated by a series of preclinical and clinical studies. In this article, different scientific databases were searched to retrieve studies depicting the biological activities of chalcones and their derivatives. This review comprehensively describes preclinical studies on chalcones and their derivatives describing their immense significance as antidiabetic, anticancer, anti-inflammatory, antimicrobial, antioxidant, antiparasitic, psychoactive, and neuroprotective agents. Besides, clinical trials revealed their use in the treatment of chronic venous insufficiency, skin conditions, and cancer. Bioavailability studies on chalcones and derivatives indicate possible hindrance and improvement in relation to its nutraceutical and pharmaceutical applications. Multifaceted and complex underlying mechanisms of chalcone actions demonstrated their ability to modulate a number of cancer cell lines, to inhibit a number of pathological microorganisms and parasites, and to control a number of signaling molecules and cascades related to disease modification. Clinical studies on chalcones revealed general absence of adverse effects besides reducing the clinical signs and symptoms with decent bioavailability. Further studies are needed to elucidate their structure activity, toxicity concerns, cellular basis of mode of action, and interactions with other molecules.
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影响因子：
6.7
作者：
Andrighetti-Frohner, Carla R.;de Oliveira, Kely N.;Castro, Helena C.
通讯作者：
Castro, Helena C.
影响因子：
2.1
作者：
Acharjee, Satarupa;Maity, Tapan Kumar;Mondal, Arijit
通讯作者：
Mondal, Arijit
影响因子：
3.8
作者：
Bak, Eun Jung;Park, Hong Gyu;Cha, Jeong-Heon
通讯作者：
Cha, Jeong-Heon
影响因子：
2.7
作者：
Bandgar, Babasaheb P.;Patil, Sachin A.;Jalde, Shivkumar S.
通讯作者：
Jalde, Shivkumar S.
影响因子：
3.5
作者：
Bello, Murilo Lamim;Chiaradia, Louise Domeneghini;Rodrigues, Carlos Rangel
通讯作者：
Rodrigues, Carlos Rangel