Using electrophoretic exclusion to manipulate small molecules and particles on a microdevice.

Using electrophoretic exclusion to manipulate small molecules and particles on a microdevice.
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DOI:
10.1002/elps.201100622
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发表时间:
2012-04
期刊:
影响因子:
2.9
通讯作者:
Hayes, Mark A.
Hayes, Mark A.
中科院分区:
生物学3区
文献类型:
--
作者:
Kenyon, Stacy M.;Weiss, Noah G.;Hayes, Mark A.

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Electrophoretic exclusion, a novel separations technique that differentiates species in bulk solution using the opposing forces of electrophoretic velocity and hydrodynamic flow, has been adapted to a microscale device. Proof-of-principle experiments indicate the device was able to exclude small particles (1 μm polystyrene microspheres) and fluorescent dye molecules (rhodamine 123) from the entrance of a channel. Additionally, differentiation of the rhodamine 123 and polystyrene spheres was demonstrated. The current studies focus on the direct observation of the electrophoretic exclusion behavior on a microchip.
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