Near-infrared-induced IR780-loaded PLGA nanoparticles for photothermal therapy to treat breast cancer metastasis in bones.

Near-infrared-induced IR780-loaded PLGA nanoparticles for photothermal therapy to treat breast cancer metastasis in bones.
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近红外诱导的 IR780 负载 PLGA 纳米颗粒用于光热疗法治疗乳腺癌骨转移

DOI:
10.1039/c9ra05813c
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发表时间:
2019-11-04
期刊:
影响因子:
3.9
通讯作者:
Wang, Long
Wang, Long
中科院分区:
化学3区
文献类型:
--
作者:
Li, Jingyi;Hu, Huiyu;Jiang, Zichao;Chen, Sijie;Pan, Yixiao;Guo, Qi;Xing, Qiqi;Jing, Zhaocheng;Hu, Yihe;Wang, Long

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Nanodrug-based cancer therapy, especially when treating bone metastases, faces the problem of limited therapeutic efficacy. In this work, we reported a photothermally triggered nanomaterial based on IR780-entrapped poly-lactide-co-glycolide (PLGA) nanoparticles (IR780@PLGA NPs) for the photothermal therapy of bone metastases of breast cancer, in which IR780 converted light into heat to play a role in “burning” the tumors. Anti-tumor therapy studies showed the impressive effectiveness of IR780@PLGA NPs in the photothermal therapy (PTT) of bone metastases. As a result, the IR780@PLGA NPs show a great potential for controlling the bone metastases of breast cancer.
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