Epigenetic determinants of healthy and diseased brain aging and cognition.
Epigenetic determinants of healthy and diseased brain aging and cognition.
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DOI：
10.1001/jamaneurol.2013.1459
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发表时间：
2013-06
期刊：
影响因子：
29
通讯作者：
Haroutunian, Vahram
中科院分区：
文献类型：
--
作者：
Akbarian, Schahram;Beeri, Michal Schnaider;Haroutunian, Vahram
更好地了解正常和患病的大脑老化和认知将对公共卫生产生重大影响，因为85岁以上的高龄老人是发达国家人口中增长最快的部分，预计到2040年，全世界每年将出现3 000多万新的痴呆症病例。基因表达的失调，以及更普遍的基因组组织和功能的失调，被认为是与年龄相关的认知能力下降的原因。值得注意的是，几乎所有存在于老年大脑中的神经元细胞核在产前发育期间都永久退出了细胞周期，DNA甲基化和组蛋白修饰以及表观基因组的其他分子成分可能在整个生命周期中维持神经元健康和功能方面发挥关键作用。在这里，我们概述了大脑染色质结构中与年龄相关的变化，强调了认知能力下降和与年龄相关的神经退行性疾病的潜在表观遗传药物靶点，并讨论了在衰老研究中研究“表观遗传生物标志物”时的机遇和挑战。
A better understanding of normal and diseased brain aging and cognition will have a significant public health impact, given that the oldest-old persons over 85 years of age represent the fastest growing segment in the population in developed countries, with over 30 million new cases of dementia predicted to occur world-wide each year by 2040. Dysregulation of gene expression, and more generally, genome organization and function, is thought to contribute to age-related declines in cognition. Remarkably, nearly all neuronal nuclei that reside in an aged brain had permanently exited from the cell cycle during prenatal development, and DNA methylation and histone modifications and other molecular constituents of the epigenome are likely to play a critical role in the maintenance of neuronal health and function throughout the entire lifespan. Here, we provide an overview on age-related changes in the brain’s chromatin structures, highlight potential epigenetic drug targets for cognitive decline and age-related neurodegenerative disease and discuss opportunities and challenges when studying ‘epigenetic biomarkers’ in aging research.
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DOI：
10.1523/jneurosci.1758-09.2009
发表时间：
2009-09-16
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Covington HE 3rd;Maze I;LaPlant QC;Vialou VF;Ohnishi YN;Berton O;Fass DM;Renthal W;Rush AJ 3rd;Wu EY;Ghose S;Krishnan V;Russo SJ;Tamminga C;Haggarty SJ;Nestler EJ
通讯作者：
Nestler EJ
影响因子：
168.9
作者：
Christensen, Kaare;Doblhammer, Gabriele;Rau, Roland;Vaupel, James W.
通讯作者：
Vaupel, James W.
影响因子：
64.5
作者：
Bhutani N;Burns DM;Blau HM
通讯作者：
Blau HM
影响因子：
7.5
作者：
Belmont, Andrew S.
通讯作者：
Belmont, Andrew S.
影响因子：
5.3
作者：
Baltan, Selva;Murphy, Sean P.;Morrison, Richard S.
通讯作者：
Morrison, Richard S.