The Metabolic and Non-Metabolic Roles of UCK2 in Tumor Progression.
The Metabolic and Non-Metabolic Roles of UCK2 in Tumor Progression.
复制标题
UCK2 在肿瘤进展中的代谢和非代谢作用
DOI：
10.3389/fonc.2022.904887
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发表时间：
2022
影响因子：
4.7
通讯作者：
Wu, Hailong
中科院分区：
文献类型：
--
作者：
Fu, Yi;Wei, Xin-dong;Guo, Luoting;Wu, Kai;Le, Jiamei;Ma, Yujie;Kong, Xiaoni;Tong, Ying;Wu, Hailong
关键词：
Enhanced nucleoside metabolism is one of the hallmarks of cancer. Uridine-cytidine kinase 2 (UCK2) is a rate-limiting enzyme of the pyrimidine salvage synthesis pathway to phosphorylate uridine and cytidine to uridine monophosphate (UMP) and cytidine monophosphate (CMP), respectively. Recent studies have shown that UCK2 is overexpressed in many types of solid and hematopoietic cancers, closely associates with poor prognosis, and promotes cell proliferation and migration in lung cancer and HCCs. Although UCK2 is thought to catalyze sufficient nucleotide building blocks to support the rapid proliferation of tumor cells, we and other groups have recently demonstrated that UCK2 may play a tumor-promoting role in a catalytic independent manner by activating oncogenic signaling pathways, such as STAT3 and EGFR-AKT. By harnessing the catalytic activity of UCK2, several cytotoxic ribonucleoside analogs, such as TAS-106 and RX-3117, have been developed for UCK2-mediated cancer chemotherapy. Moreover, we have demonstrated that the concurrent targeting of the catalytic dependent and independent features of UCK2 could synergistically inhibit tumor growth. These findings suggest that UCK2 may serve as a potential therapeutic target for cancer treatment. In this mini-review, we introduced the genomic localization and protein structure of UCK2, described the role of UCK2 in tumor development, discussed the application of UCK2 in anti-tumor treatment, and proposed concurrent targeting of the catalytic and non-catalytic roles of UCK2 as a potential therapeutic strategy for cancer treatment.
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影响因子：
1.7
作者：
Przybyla, Tomasz;Sakowicz-Burkiewicz, Monika;Pawelczyk, Tadeusz
通讯作者：
Pawelczyk, Tadeusz
胞苷类似物氟环戊烯基胞嘧啶 (RX-3117) 由尿苷-胞苷激酶 2 激活。
影响因子：
3.7
作者：
Sarkisjan D;Julsing JR;Smid K;de Klerk D;van Kuilenburg AB;Meinsma R;Lee YB;Kim DJ;Peters GJ
通讯作者：
Peters GJ
DOI：
10.1111/j.1349-7006.2002.tb01325.x
发表时间：
2002-07
期刊：
Japanese journal of cancer research : Gann
影响因子：
--
作者：
Shimamoto Y;Koizumi K;Okabe H;Kazuno H;Murakami Y;Nakagawa F;Matsuda A;Sasaki T;Fukushima M
通讯作者：
Fukushima M
高良姜根茎中的粗提物、黄酮素 B 和高山姜素化合物通过 UCK2 酶抑制诱导细胞死亡，进而减少 HT-29 细胞中 18S rRNA 的生物合成。
影响因子：
3.7
作者：
Malami I;Abdul AB;Abdullah R;Kassim NK;Rosli R;Yeap SK;Waziri P;Etti IC;Bello MB
通讯作者：
Bello MB
UCK2 的非代谢作用将 EGFR-AKT 通路激活与肝细胞癌的转移增强联系起来
影响因子：
6.2
作者：
Cai J;Sun X;Guo H;Qu X;Huang H;Yu C;Wu H;Gao Y;Kong X;Xia Q
通讯作者：
Xia Q