Intravascular magnetic resonance imaging of aortic atherosclerotic plaque composition.
Intravascular magnetic resonance imaging of aortic atherosclerotic plaque composition.
复制标题
主动脉粥样硬化斑块成分的血管内磁共振成像。
DOI：
10.1161/01.atv.17.12.3626
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
Lima,JA
中科院分区：
文献类型：
--
作者：
Correia,LC;Atalar,E;Kelemen,MD;Ocali,O;Hutchins,GM;Fleg,JL;Gerstenblith,G;Zerhouni,EA;Lima,JA
磁共振成像(MRI)可能是确定动脉粥样硬化斑块组成的一种很好的工具，但表面MRI(SMRI)存在低信噪比和动脉图像低分辨率的问题。血管内磁共振成像(IVMRI)是获取动脉粥样硬化斑块的高质量活体图像的潜在解决方案。在尸检中获得的11个人体胸主动脉的分离节段进行了IVMRI成像，使用的是我所设计和制造的血管内接收器导管线圈。将IVMRI获得的图像与SMRI获得的相应图像进行比较，并与组织病理学的主动脉横断面进行比较。血管内膜厚度和斑块成分的强度按IVMRI和组织病理学分级，轻度1分，中度2分，重度3分。IVMRI在纤维帽分级(37.5%，κ=0.6，P<；0.001)和坏死核分级(39%，κ=0.57，P<；0.001)方面与组织病理学的符合率为75%。在组织病理学识别钙的8个斑块中，有6个斑块内钙化通过IVMRI正确分级。血管内膜厚度分析显示，IVMRI与组织病理学的符合率为80%(52%为预期，κ=0.59P<；0.001)。IVMRI图像特征与SMRI相似。此外，与组织病理学和SMRI相比，IVMRI能准确地确定斑块的大小(IVMRI对管腔面积的斜率=1.25cm2，r=0.99，P<0.001；对管腔面积的斜率=0.97cm2，r=0.996，P<0.001)。IVMRI有可能为动脉粥样硬化患者提供重要的预后信息，因为它能够准确评估斑块的成分和大小。
Magnetic resonance imaging (MRI) may be an excellent tool to define atherosclerotic plaque composition, but surface MRI (SMRI) suffers from a low signal-to-noise ratio and low resolution of arterial images. Intravascular MRI (IVMRI) represents a potential solution for acquiring high-quality in vivo images of atherosclerotic plaques. Isolated segments of 11 thoracic human aortas obtained at autopsy were imaged by IVMRI using an intravascular receiver catheter coil designed and built at our institution. Images obtained by IVMRI were compared with corresponding images obtained by SMRI and with histopathological aortic cross sections. The intensity of intimal thickness and plaque components was graded by IVMRI and histopathology using a score of 1 for mild, 2 for moderate, and 3 for severe intensity. IVMRI had an agreement of 75% with histopathology in fibrous cap grading (37.5% expected, κ=0.60,P<0.001) and of 74% in necrotic core grading (39% expected, κ=0.57,P<0.001). Intraplaque calcification was correctly graded by IVMRI in six of the eight plaques in which histopathology recognized calcium. The analysis of intimal thickness showed 80% agreement between IVMRI and histopathology (52% expected, κ=0.59,P<0.001). IVMRI image features were similar to those of SMRI. In addition, IVMRI accurately determined atherosclerotic plaque size in comparison with histopathology and SMRI (slope=1.25 cm2,r=0.99,P<0.001 for luminal area by IVMRI vs histopathology; slope=0.97 cm2,r=0.996,P<0.001 for luminal area by IVMRI vs SMRI). IVMRI has the potential to provide important prognostic information in patients with atherosclerosis because of its ability to accurately assess both plaque composition and size.
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人类冠状动脉粥样斑块的核磁共振显微镜检查
影响因子：
2.8
作者：
J. Pearlman;J. Southern;J. Ackerman
通讯作者：
J. Ackerman
影响因子：
3.3
作者：
HURST, GC;HUA, JM;COHEN, AM
通讯作者：
COHEN, AM
DOI：
10.1016/0735-1097(93)90714-c
发表时间：
1993-01-01
影响因子：
24
作者：
HODGSON, JM;REDDY, KG;SHEEHAN, HM
通讯作者：
SHEEHAN, HM
原型微型腔内 MR 成像导管。
影响因子：
2.9
作者：
K. Kandarpa;P. Jakab;S. Patz;F. Schoen;F. Jolesz
通讯作者：
F. Jolesz
经皮球囊血管成形术前后的血管造影、血管镜检查和超声成像。
影响因子：
4.8
作者：
R. Siegel;J. Chae;J. Forrester;C. Ruiz
通讯作者：
C. Ruiz