The Impact of Body Mass Index and Waist Circumference on Health-related Quality of Life Among Colorectal Cancer Survivors: Results from the PROFILES Registry
The Impact of Body Mass Index and Waist Circumference on Health-related Quality of Life Among Colorectal Cancer Survivors: Results from the PROFILES Registry
复制标题
体重指数和腰围对结直肠癌幸存者健康相关生活质量的影响：PROFILES 登记结果
DOI：
10.1080/01635581.2017.1367938
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
S. Beijer
中科院分区：
文献类型：
--
作者：
P. Vissers;R. Martucci;F. Mols;M. Bours;R. Winkels;E. Kampman;M. Weijenberg;L. V. van de Poll;S. Beijer
摘要背景：我们的目的是评估结直肠癌 (CRC) 幸存者的腰围 (WC) 和体重指数 (BMI) 与健康相关生活质量 (HRQL) 的关系。方法：2000 年至 2009 年间诊断的 CRC 幸存者于 2013 年 8 月（自我报告体重、身高和自我评估 WC）和 2014 年 1 月（使用 EORTC-QLQ-C30 进行 HRQL）完成问卷调查。临床特征取自荷兰癌症登记处。在多变量线性回归分析中，评估了仅 BMI、仅 WC 以及 BMI 和 WC 与 HRQL 结果的关联。结果：1,111 名 CRC 幸存者被纳入其中，其中 34% 体重正常（18.5 ≤ BMI < 25 kg/m2），49% 超重（25 ≤ BMI < 30 kg/m2），17% 肥胖（BMI ≥ 30 kg/m2），44% WC 增加（即男性和女性>102 和>88 cm，分别）。 BMI 和 WC 分别与较差的整体健康状况、功能和更多疲劳症状相关。无论 BMI 如何，WC 增加都与较低的身体、角色和情绪功能相关，平均差异在 3 到 5 点之间。结论：未来关于 CRC 幸存者 HRQL 的研究应同时考虑 BMI 和 WC。此外，减肥试验不仅应关注一般体重减轻，还应关注腹部脂肪的减少。
ABSTRACT Background: We aimed to assess the association of waist circumference (WC) and body mass index (BMI) with health-related quality of life (HRQL) among colorectal cancer (CRC) survivors. Methods: CRC survivors diagnosed between 2000 and 2009 completed questionnaires in August 2013 (with self-reported weight, height, and self-assessed WC) and January 2014 (with HRQL using the EORTC-QLQ-C30). Clinical characteristics were retrieved from the Netherlands Cancer Registry. In multivariable linear regression analyses associations of BMI only, WC only and both BMI and WC with HRQL outcomes were assessed. Results: 1,111 CRC survivors were included of whom 34% had a normal weight (18.5 ≤ BMI < 25 kg/m2), 49% had overweight (25 ≤ BMI < 30 kg/m2), 17% had obesity (BMI ≥ 30 kg/m2), and 44% had an increased WC (i.e., >102 and >88 cm for men and women, respectively). Both BMI and WC were separately associated with worse global health status, functioning, and more symptoms of fatigue. Increased WC was associated with lower physical, role and emotional functioning, regardless of BMI, with average differences ranging between 3 and 5 points. Conclusion: Future research on HRQL among CRC survivors should consider both BMI and WC. Furthermore, weight reduction trials should not only focus on general weight loss but also on the loss of abdominal fat.
影响因子：
4.4
作者：
Leon, Barbara G. Carranza;Jensen, Michael D.;Jensen, Teresa B.
通讯作者：
Jensen, Teresa B.
影响因子：
5.8
作者：
Trentham-Dietz, A;Remington, PL;Newcomb, PA
通讯作者：
Newcomb, PA
影响因子：
39.3
作者：
Ortega, Francisco B.;Lee, Duck-chul;Blair, Steven N.
通讯作者：
Blair, Steven N.