Distribution of interneurons in the CA2 region of the rat hippocampus.
Distribution of interneurons in the CA2 region of the rat hippocampus.
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DOI：
10.3389/fnana.2014.00104
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发表时间：
2014
影响因子：
2.9
通讯作者：
Mercer A
中科院分区：
文献类型：
--
作者：
Botcher NA;Falck JE;Thomson AM;Mercer A
哺乳动物海马体的 CA2 区域是一个独特的区域，具有自己独特的特性、输入和病理。该区域抑制回路的破坏似乎与特定精神疾病的病理有关，促进了人们对其局部回路、其在海马功能中的作用及其在疾病中的功能障碍的兴趣。在之前的研究中，CA2中间神经元，包括尚未在其他CA区域中发现的CA2树突偏好中间神经元的新亚类，已被证明显示出该子领域独特的生理、突触和形态特性，因此可能在海马回路中发挥至关重要的作用。研究了背侧 CA2 中免疫标记的中间神经元的分布，并与 CA1 和 CA3 中的中间神经元的分布进行了比较。与 CA1 和 CA3 中的细胞一样，CA2 小白蛋白免疫过氧化物酶标记的中间神经元的体细胞主要位于金字塔层 (SP) 和东方层 (SO)，放射层 (SR) 中细胞很少，而空穴分子层 (SLM) 中没有细胞。然而，CA2 SP 中 PV 免疫阳性的 GAD 阳性细胞比例高于 CA1 或 CA3。 CA2 SP 还含有比 CA1 和/或 CA3 更高密度的生长抑素、钙结合蛋白和 VIP 免疫阳性体细胞。与CA1和CA3中的CCK免疫阳性体细胞一样，CA2中的CCK免疫阳性体体主要位于SR中。 Reelin 和 NPY 免疫标记的细胞体位于三个 CA 区域的所有层中。然而，CA2 的 SP 和 SR 中的 Reelin 阳性体细胞密度高于 CA1 或 CA3。
The CA2 region of the mammalian hippocampus is a unique region with its own distinctive properties, inputs and pathologies. Disruption of inhibitory circuits in this region appears to be linked with the pathology of specific psychiatric disorders, promoting interest in its local circuitry, its role in hippocampal function and its dysfunction in disease. In previous studies, CA2 interneurons, including a novel subclass of CA2 dendrite-preferring interneurons that has not been identified in other CA regions, have been shown to display physiological, synaptic and morphological properties unique to this sub-field and may therefore play a crucial role in the hippocampal circuitry. The distributions of immuno-labeled interneurons in dorsal CA2 were studied and compared with those of interneurons in CA1 and CA3. Like those in CA1 and CA3, the somata of CA2 parvalbumin-immunoperoxidase-labeled interneurons were located primarily in Stratum Pyramidale (SP) and Stratum Oriens (SO), with very few cells in Stratum Radiatum (SR) and none in Stratum Lacunosum Moleculare (SLM). There was, however, a greater proportion of GAD-positive cells were immunopositive for PV in SP in CA2 than in CA1 or CA3. CA2 SP also contained a larger density of somatostatin-, calbindin-, and VIP-immunopositive somata than CA1 and/or CA3. Like those in CA1 and CA3, CCK-immunopositive somata in CA2 were mostly located in SR. Reelin- and NPY- immunolabeled cell bodies were located in all layers of the three CA regions. However, a higher density of Reelin-positive somata was found in SP and SR of CA2 than in CA1 or CA3.
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影响因子：
16.2
作者：
Chevaleyre V;Siegelbaum SA
通讯作者：
Siegelbaum SA
影响因子：
2.5
作者：
Burette, Alain C.;Strehler, Emanuel E.;Weinberg, Richard J.
通讯作者：
Weinberg, Richard J.
影响因子：
2.9
作者：
BAIMBRIDGE, KG;MILLER, JJ
通讯作者：
MILLER, JJ
影响因子：
3.5
作者：
Bartesaghi, R;Gessi, T
通讯作者：
Gessi, T
影响因子：
5.3
作者：
Goldin, Miri;Epsztein, Jerome;Cossart, Rosa
通讯作者：
Cossart, Rosa