Trichloroethylene, a ubiquitous environmental contaminant in the risk for Parkinson's disease.
Trichloroethylene, a ubiquitous environmental contaminant in the risk for Parkinson's disease.
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DOI：
10.1039/c9em00578a
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发表时间：
2020-03-01
期刊：
影响因子：
--
通讯作者：
Greenamyre JT
中科院分区：
文献类型：
--
作者：
De Miranda BR ;Greenamyre JT
有机溶剂是全世界工业中常用的化学品，然而，有证据表明接触这些化合物会对健康产生不利影响。三氯乙烯（TCE）是一种卤化溶剂，自世纪初以来一直用作消毒剂。由于其广泛使用，TCE仍然是美国最重要的环境污染物之一，广泛的研究表明，TCE是许多疾病的致病因素，包括癌症，胎儿心脏发育和神经毒性。TCE也被认为是最常见的神经退行性运动障碍帕金森病（PD）发展的可能风险因素。然而，在评估三氯乙烯（或溶剂）暴露和帕金森病风险的多项职业流行病学研究中存在可变的一致性。此外，关于三氯乙烯如何增强多巴胺能系统的毒性，仍存在一定程度的不确定性。为此，我们回顾了特定的神经毒性机制的TCE的背景下，多巴胺能神经元的选择性脆弱性。此外，我们考虑了最终导致神经变性的综合风险因素的复杂性，并讨论了单因素暴露评估的局限性。
Organic solvents are common chemicals used in industry throughout the world, however, there is evidence for adverse health effects from exposure to these compounds. Trichloroethylene (TCE) is a halogenated solvent that has been used as a degreasing agent since the early 20th century. Due to its widespread use, TCE remains one of the most significant environmental contaminants in the US, and extensive research suggests TCE is a causative factor in a number of diseases, including cancer, fetal cardiac development, and neurotoxicity. TCE has also been implicated as a possible risk factor in the development of the most common neurodegenerative movement disorder, Parkinson’s disease (PD). However, there is variable concordance across multiple occupational epidemiological studies assessing TCE (or solvent) exposure and risk for PD. In addition, there remains a degree of uncertainty about how TCE elicits toxicity to the dopaminergic system. To this end, we review the specific neurotoxic mechanisms of TCE in the context of selective vulnerability of dopaminergic neurons. In addition, we consider the complexity of combined risk factors that ultimately contribute to neurodegeneration and discuss the limitations of single-factor exposure assessments.
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