Dietary mercury exposure resulted in behavioral differences in mice contaminated with fish-associated methylmercury compared to methylmercury chloride added to diet.
Dietary mercury exposure resulted in behavioral differences in mice contaminated with fish-associated methylmercury compared to methylmercury chloride added to diet.
复制标题
饮食汞暴露导致与饮食中添加的甲基汞氯化物相比，与鱼类相关的甲基汞污染的小鼠的行为差异。
DOI：
10.1155/2012/681016
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发表时间：
2012
影响因子：
--
通讯作者：
Fujimura M
中科院分区：
文献类型：
--
作者：
Bourdineaud JP;Marumoto M;Yasutake A;Fujimura M
甲基汞（MeHg）是一种强有力的神经毒素，人类主要通过食用鱼类接触这种污染物。然而，在传统的毒理学研究中，纯氯化甲基汞（MeHgCl）被注射、饮用或掺入饲料中，假设其影响与鱼类天然相关的甲基汞相同。在本研究中，我们想解决的问题是，与含有相同浓度的纯甲基汞的饮食相比，含有与鱼类相关的甲基汞的饮食是否会对小鼠产生明显的不良影响，以及鱼类的有益营养是否能够抵消与鱼类相关的汞的有害影响（如果有的话）。经过两个月的喂养，含鱼的饮食导致显着的可观察到的效果相比，控制和含甲基汞的饮食，包括改变行为的表现，在Y形迷宫和一个开放的领域，并增加多巴胺代谢周转在海马体中，尽管事实上，含鱼的饮食富含多不饱和脂肪酸和硒相比，无鱼的饮食。
Methylmercury (MeHg) is a potent neurotoxin, and humans are mainly exposed to this pollutant through fish consumption. However, in classical toxicological studies, pure methylmercury chloride (MeHgCl) is injected, given to drink or incorporated within feed assuming that its effects are identical to those of MeHg naturally associated to fish. In the present study, we wanted to address the question whether a diet containing MeHg associated to fish could result in observable adverse effects in mice as compared to a diet containing the same concentration of MeHg added pure to the diet and whether beneficial nutriments from fish were able to counterbalance the deleterious effects of fish-associated mercury, if any. After two months of feeding, the fish-containing diet resulted in significant observable effects as compared to the control and MeHg-containing diets, encompassing altered behavioral performances as monitored in a Y-shaped maze and an open field, and an increased dopamine metabolic turnover in hippocampus, despite the fact that the fish-containing diet was enriched in polyunsaturated fatty acids and selenium compared to the fish-devoid diets.
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