Homosexual men with thrombocytopenia have impaired reticuloendothelial system Fc receptor-specific clearance
Homosexual men with thrombocytopenia have impaired reticuloendothelial system Fc receptor-specific clearance
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患有血小板减少症的同性恋男性网状内皮系统 Fc 受体特异性清除受损
DOI：
10.1182/blood.v70.2.392.bloodjournal702392
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发表时间：
1987
期刊：
影响因子：
20.3
通讯作者：
J. Spivak
中科院分区：
文献类型：
--
作者：
B. Bender;T. Quinn;J. Spivak
经典的免疫性血小板减少性紫癜（ITP）主要发生在女性，与正常或受损的Fc受体介导的抗体包被细胞清除有关。最近，在同性恋男性中观察到血小板减少症的发病率增加，但Fc受体介导的抗体包被细胞清除在这些男性中是否正常或受损尚不清楚。为了研究这个问题，我们测量了5名患有血小板减少症的同性恋男性体内抗Rho（D）IgG抗体致敏的51 Cr标记自体红细胞的清除率。所有五个人都有人类免疫缺陷病毒的抗体，四个人有循环免疫复合物，通过Clq结合试验确定。其中两名受试者的血小板相关IgG也有所增加。在血小板计数为20，000/μ L或更低的四名同性恋男性中，IgG致敏红细胞的清除半衰期延长（平均值为106分钟;范围为72至140分钟），而在五名血液学正常男性中，此类细胞的清除时间延长（平均值为39分钟;范围为30至50分钟; P <0.005）。一名血小板计数为81，000/μ L的同性恋男子的清除半衰期正常（30分钟）。对皮质类固醇治疗后血小板计数升高的3例患者进行了再研究。在这三个病例中，抗体包被细胞的清除率缩短，并在一名完全缓解的患者中恢复正常。未观察到血小板相关IgG或循环免疫复合物的存在与清除半衰期之间的相关性。这些数据表明，严重的血小板减少症发生在同性恋男性，在一些典型的ITP患者与缺陷的体内Fc受体介导的抗体包被细胞的清除。
Classic immune thrombocytopenia purpura (ITP) occurs predominantly in women and is associated with either normal or impaired Fc receptor-mediated clearance of antibody-coated cells. Recently, an increasing incidence of thrombocytopenia has been observed in homosexual men, but whether Fc receptor-mediated clearance of antibody-coated cells is normal or impaired in these men is unknown. To study this question, we measured the in vivo clearance of anti-Rho(D) IgG antibody-sensitized 51Cr-labeled autologous red cells in five homosexual men with thrombocytopenia without an evident cause. All five had antibodies to human immunodeficiency virus, and four had circulating immune complexes as determined by a Clq-binding assay. Two of the men tested also had an increase in platelet-associated IgG. In the four homosexual men with platelet counts of 20,000/microL or less, the clearance half-time of IgG-sensitized red cells was prolonged (mean, 106 minutes; range, 72 to 140 minutes) as compared with the clearance of such cells in five hematologically normal men (mean, 39 minutes; range 30 to 50 minutes; P less than .005). One homosexual man with a platelet count of 81,000/microL had a normal clearance half-time (30 minutes). Three patients whose platelet counts increased after corticosteroid therapy were restudied. In all three, the clearance of antibody-coated cells was shortened and returned to normal in the one patient who had achieved a complete remission. No correlation was observed between the presence of platelet-associated IgG or circulating immune complexes and the clearance half-time. These data indicate that severe thrombocytopenia occurring in homosexual men as in some patients with classic ITP is associated with defective in vivo Fc receptor-mediated clearance of antibody-coated cells.
患有免疫性血小板减少症的同性恋男性的目标血小板抗原。
DOI：
10.1056/nejm198511283132202
发表时间：
1985
期刊：
The New England journal of medicine
影响因子：
--
作者：
Stricker,RB;Abrams,DI;Corash,L;Shuman,MA
通讯作者：
Shuman,MA
性活跃的同性恋男性血小板减少性紫癜的机制。
DOI：
10.1056/nejm198409063111004
发表时间：
1984
期刊：
The New England journal of medicine
影响因子：
--
作者：
Walsh,CM;Nardi,MA;Karpatkin,S
通讯作者：
Karpatkin,S