Emerging Themes in the Molecular Pathogenesis of Enterotoxigenic Escherichia coli.
Emerging Themes in the Molecular Pathogenesis of Enterotoxigenic Escherichia coli.
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DOI：
10.1093/infdis/jiab359
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发表时间：
2021-12-20
期刊：
影响因子：
--
通讯作者：
Sheikh A
中科院分区：
文献类型：
--
作者：
Fleckenstein JM;Sheikh A
产肠毒素大肠杆菌（ETEC）是普遍存在的肠道病原体，在缺乏清洁水和卫生设施的基本人类需求的地区蓬勃发展。这些具有遗传可塑性的有机体在处境不利的幼儿中造成了巨大的发病率，表现为急性腹泻病以及营养不良和发育障碍的后遗症。最近发现的其他质粒编码的毒力因子和阐明其在ETEC的分子发病机制中的关键作用，可能会为开发广泛保护性疫苗提供新的方法。虽然病原体在流行病学上与非创伤性后遗症密切相关，但对这些疾病的了解仍然很少。同样，虽然ETEC毒素对促进腹泻的细胞信号传导的典型影响是明确的，但新出现的数据表明，这些毒素也可能导致肠道结构的变化和相关后遗症。阐明这些变化背后的分子事件可以为预防急性腹泻和ETEC相关后遗症的疫苗提供最佳方法。
Enterotoxigenic Escherichia coli (ETEC) are ubiquitous diarrheal pathogens that thrive in areas lacking basic human needs of clean water and sanitation. These genetically plastic organisms cause tremendous morbidity among disadvantaged young children, in the form of both acute diarrheal illness and sequelae of malnutrition and growth impairment. The recent discovery of additional plasmid-encoded virulence factors and elucidation of their critical role in the molecular pathogenesis of ETEC may inform new approaches to the development of broadly protective vaccines. Although the pathogens have been closely linked epidemiologically with nondiarrheal sequelae, these conditions remain very poorly understood. Similarly, while canonical effects of ETEC toxins on cellular signaling promoting diarrhea are clear, emerging data suggest that these toxins may also drive changes in intestinal architecture and associated sequelae. Elucidation of molecular events underlying these changes could inform optimal approaches to vaccines that prevent acute diarrhea and ETEC-associated sequelae.
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影响因子：
13.6
作者：
Korpe PS;Petri WA Jr
通讯作者：
Petri WA Jr
影响因子：
3.1
作者：
Fleckenstein, JM;Roy, KS;Burkitt, M
通讯作者：
Burkitt, M
影响因子：
15.9
作者：
Kumar, Pardeep;Kuhlmann, F. Matthew;Fleckenstein, James M.
通讯作者：
Fleckenstein, James M.
DOI：
10.1111/j.1349-7006.1990.tb02600.x
发表时间：
1990-05
期刊：
Japanese journal of cancer research : Gann
影响因子：
--
作者：
Matsuoka Y;Matsuo Y;Sugano K;Ohkura H;Kuroki M;Kuroki M
通讯作者：
Kuroki M
影响因子：
34.3
作者：
Kotloff, Karen L.;Nasrin, Dilruba;Levine, Myron M.
通讯作者：
Levine, Myron M.