Lectin and mucin histochemistry as an aid to cancer surveillance in ulcerative colitis
Lectin and mucin histochemistry as an aid to cancer surveillance in ulcerative colitis
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凝集素和粘蛋白组织化学有助于溃疡性结肠炎的癌症监测
DOI：
10.1111/j.1365-2559.1987.tb02643.x
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发表时间：
1987
期刊：
影响因子：
6.4
通讯作者：
G. Giles
中科院分区：
文献类型：
--
作者：
J. Fozard;M. Dixon;A. Axon;G. Giles
在一项初步研究中，我们评估了10种凝集素用于鉴别溃疡性结肠炎患者结肠切除术标本中的不典型增生。花生凝集素（PNA）结合发现在所有的不典型增生病例。在主要研究中，研究了115例溃疡性结肠炎合并癌患者（n=6）和因医疗管理失败而行直结肠切除术的患者（n=8）的术前结肠镜活检和术后切除标本中PNA染色、高铁二胺/阿利新蓝（HID‐AB）组织化学与不典型增生之间的关系。花生凝集素在评估癌前病变或癌症风险方面没有价值。然而，HID - AB染色似乎澄清了不太严重的恶性前病变的解释，并可能有效地应用于解释溃疡性结肠炎的结肠镜活检的癌症监测。
In a preliminary study, we assessed 10 lectins for the identification of dysplasia in colectomy specimens from patients with ulcerative colitis. Peanut agglutinin (PNA) binding was found in all cases of dysplasia. In the main study the relationship between PNA staining, high iron‐diamine/alcian blue (HID‐AB) histochemistry, and dysplasia was investigated in 115 pre‐operative colonoscopic biopsies and the subsequent resection specimens from patients with ulcerative colitis complicated by carcinoma (n=6) and patients undergoing proctocolectomy for failure of medical management (n=8). Peanut lectin was of no value in the assessment of pre‐malignant changes or cancer risk. However, the HID‐AB stain appears to clarify the interpretation of less severe pre‐malignant changes and may be usefully applied to the interpretation of colonoscopic biopsies for cancer surveillance in ulcerative colitis.
影响因子：
24.5
作者：
BOLAND, CR;LANCE, P;KIM, YS
通讯作者：
KIM, YS