Therapeutic potential of plant iridoids in depression: a review.
Therapeutic potential of plant iridoids in depression: a review.
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DOI：
10.1080/13880209.2022.2136206
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发表时间：
2022-12
影响因子：
3.8
通讯作者：
Zhao, Ye
中科院分区：
文献类型：
--
作者：
Kou, Yaoyao;Li, Zhihao;Yang, Tong;Shen, Xue;Wang, Xin;Li, Haopeng;Zhou, Kun;Li, Luyao;Xia, Zhaodi;Zheng, Xiaohui;Zhao, Ye
抑郁症是一种精神障碍，其特征是情绪低落，兴趣减退，认知功能受损，以及睡眠障碍或食欲不振等植物性症状。环烯醚萜类化合物是月菊丸、知子厚朴汤、知子赤汤、白鹤地黄汤等几种中国古典抗抑郁方中的有效成分。与环烯醚类化合物的广泛用途类似，环烯醚类化合物被认为是治疗神经疾病的潜在先导化合物。综述了环烯醚萜类化合物在预防或治疗抑郁症方面的治疗潜力和分子机制，并有助于确定环烯醚萜类化合物作为潜在的抗抑郁药物的研究空白。计算机检索PubMed、Google Scholar、Web of Science和中国国家知识网，无时间限制，尽可能全面地检索所有与体内或体外实验研究相关的文章：(‘环烯醚萜’或‘塞西里多德’或‘抑郁症’)。本文综述了植物来源的环烯醚萜类化合物对抑郁症的治疗潜力及其分子机制的实验数据。植物环烯醚萜类化合物(梓醇、京尼平苷、马钱子素)和二环烯醚萜类化合物(莫诺苷、龙胆苦苷、油菜素、苦马钱素)均对抑郁有显著的改善作用。环烯醚类化合物通过升高单胺类神经递质，减少促炎因子，抑制下丘脑-垂体-肾上腺(HPA)轴的过度活动，增加脑源性神经营养因子(BDNF)及其受体，以及提高肠道微生物丰度来发挥抗抑郁作用。在未来的研究中，还需要对环烯醚衍生物的药代动力学、生物利用度和关键分子靶点进行进一步的详细研究，最终为目前的抗抑郁药物提供改进。
Depression is a mental disorder characterized by low mood, reduced interest, impaired cognitive function, and vegetative symptoms such as sleep disturbances or poor appetite. Iridoids are the active constituents in several Chinese classical antidepressant formulae such as Yueju Pill, Zhi-Zi-Hou-Po Decoction, Zhi-Zi-Chi Decoction, and Baihe Dihuang Decoction. Parallel to their wide usages, iridoids are considered potential lead compounds for the treatment of neurological diseases. The review summarizes the therapeutic potential and molecular mechanisms of iridoids in the prevention or treatment of depression and contributes to identifying research gaps in iridoids as potential antidepressant medication. The following key phrases were sought in PubMed, Google Scholar, Web of Science, and China National Knowledge Internet (CNKI) without time limitation to search all relevant articles with in vivo or in vitro experimental studies as comprehensively as possible: (‘iridoid’ or ‘seciridoid’ or ‘depression’). This review extracted the experimental data on the therapeutic potential and molecular mechanism of plant-derived iridoids for depression. Plant iridoids (i.e., catalpol, geniposide, loganin), and secoiridoids (i.e., morroniside, gentiopicroside, oleuropein, swertiamarin), all showed significant improvement effects on depression. Iridoids exert antidepressant effects by elevating monoamine neurotransmitters, reducing pro-inflammatory factors, inhibiting hypothalamic-pituitary-adrenal (HPA) axis hyperactivity, increasing brain-derived neurotrophic factor (BDNF) and its receptors, and elevating intestinal microbial abundance. Further detailed studies on the pharmacokinetics, bioavailability, and key molecular targets of iridoids are also required in future research, ultimately to provide improvements to current antidepressant medications.
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DOI：
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发表时间：
2021-01
期刊：
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影响因子：
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DOI：
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发表时间：
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期刊：
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影响因子：
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通讯作者：
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