Dosimetric impact of intra-fraction prostate motion under a tumour-tracking system in hypofractionated robotic radiosurgery.
Dosimetric impact of intra-fraction prostate motion under a tumour-tracking system in hypofractionated robotic radiosurgery.
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DOI：
10.1371/journal.pone.0195296
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发表时间：
2018
期刊：
影响因子：
3.7
通讯作者：
Ogawa K
中科院分区：
文献类型：
--
作者：
Koike Y;Sumida I;Mizuno H;Shiomi H;Kurosu K;Ota S;Yoshioka Y;Suzuki O;Tamari K;Ogawa K
对于CyberKnife介导的前列腺癌治疗，应用肿瘤跟踪方法通过间歇性获取植入基准标记的X射线图像来纠正目标位置。本研究调查了射波刀治疗期间分次内前列腺运动的剂量影响。我们回顾性分析了16例使用射波刀治疗的患者（35戈伊分5次输送）。使用记录的前列腺运动的日志文件，模拟部分内前列腺运动。我们将最差情况的部分内前列腺运动定义为日志文件上的前后偏差之间的差异，并根据每个射束的相应偏移量移动结构集。计算剂量-体积指数，并与原始计划的临床靶体积（CTV），计划靶体积（CTV加2 mm边缘），直肠，膀胱和尿道进行比较。在1929个时间戳中，分别观察到31.3%、9.1%和0.5%的前列腺运动>3、>5和>10 mm。模拟方案与原始方案的相对差异大多小于1%。尽管观察到目标的D50%和D98%显著降低，但与计划剂量相比，绝对剂量差异<0.1戈伊。即使治疗持续时间较长，部分内前列腺运动的剂量影响也可能很小，这表明使用射波刀的肿瘤跟踪可能是检查前列腺运动的稳健系统。
For CyberKnife-mediated prostate cancer treatment, a tumour-tracking approach is applied to correct the target location by acquiring X-ray images of implanted fiducial markers intermittently. This study investigated the dosimetric impact of intra-fraction prostate motion during CyberKnife treatment. We retrospectively analyzed 16 patients treated using the CyberKnife (35 Gy delivered in five fractions). Using log files of recorded prostate motion, the intra-fraction prostate motion was simulated. We defined the worst-case intra-fraction prostate motion as the difference between pre- and post-deviation on log files and shifted structure sets according to the corresponding offsets for each beam. The dose–volume indices were calculated and compared with the original plan in terms of clinical target volume (CTV), planning target volume (CTV plus a 2-mm margin), rectum, bladder, and urethra. Prostate motions of >3, >5, and >10 mm were observed for 31.3, 9.1, and 0.5% of the 1929 timestamps, respectively. Relative differences between the simulated and original plans were mostly less than 1%. Although significant decreases were observed in D50% and D98% of the target, absolute dose differences were <0.1 Gy compared with the planned dose. The dosimetric impact of intra-fraction prostate motion may be small even with longer treatment durations, indicating that the tumour tracking using the CyberKnife could be a robust system for examining prostate motion.
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影响因子：
2.1
作者：
Sumida I;Shiomi H;Higashinaka N;Murashima Y;Miyamoto Y;Yamazaki H;Mabuchi N;Tsuda E;Ogawa K
通讯作者：
Ogawa K
DOI：
10.1016/j.ijrobp.2004.09.023
发表时间：
2005-01-01
影响因子：
7
作者：
Deurloo, KEI;Steenbakkers, RJHM;van Herk, M
通讯作者：
van Herk, M
DOI：
10.1016/s0360-3016(03)00633-3
发表时间：
2003-11-01
影响因子：
7
作者：
Langen, KM;Pouliot, J;Roach, M
通讯作者：
Roach, M
DOI：
10.1016/j.ijrobp.2008.07.023
发表时间：
2008-12-01
影响因子：
7
作者：
van der Wielen, Gerard J.;Mutanga, Theodore F.;de Boer, Hans C. J.
通讯作者：
de Boer, Hans C. J.
影响因子：
2.1
作者：
Inoue, Mitsuhiro;Shiomi, Hiroya;Inoue, Tomio
通讯作者：
Inoue, Tomio