Epigenome manipulation as a pathway to new natural product scaffolds and their congeners.
Epigenome manipulation as a pathway to new natural product scaffolds and their congeners.
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DOI：
10.1039/b920860g
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发表时间：
2010-01
影响因子：
11.9
通讯作者：
Cichewicz RH
中科院分区：
文献类型：
--
作者：
Cichewicz RH
染色质的共价修饰是真菌调节次生代谢物合成相关基因转录的重要调控机制。到目前为止，针对组蛋白和DNA翻译后过程的分子和化学方法在合理指导天然产物编码基因簇的激活和/或抑制方面显示出巨大的潜力。在这一重点中，总结了真菌表观基因组的组织，并提出了操纵染色质相关靶标的策略。这些技术的应用使用了几个最近发表的报道，其中化学-表观遗传学方法和突变研究被成功地用于从头开始或增强生产结构多样化的真菌天然产物(例如，蒽醌、枝色、月桂酰胺、霉菌毒素和尼吉诺酮)。
The covalent modification of chromatin is an important control mechanism used by fungi to modulate the transcription of genes involved in secondary metabolite production. To date, both molecular-based and chemical approaches targeting histone and DNA posttranslational processes have shown great potential for rationally directing the activation and/or suppression of natural-product-encoding gene clusters. In this Highlight, the organization of the fungal epigenome is summarized and strategies for manipulating chromatin-related targets are presented. Applications of these techniques are illustrated using several recently published accounts in which chemical-epigenetic methods and mutant studies were successfully employed for the de novo or enhanced production of structurally diverse fungal natural products (e.g., anthraquinones, cladochromes, lunalides, mycotoxins, and nygerones).
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影响因子：
2.8
作者：
Challis, Gregory L.
通讯作者：
Challis, Gregory L.
影响因子：
10.5
作者：
Adhvaryu, Keyur K.;Selker, Eric U.
通讯作者：
Selker, Eric U.
影响因子：
--
作者：
Adhvaryu, KK;Morris, SA;Selker, EU
通讯作者：
Selker, EU
影响因子：
3.6
作者：
Bok, Jin Woo;Noordermeer, Daan;Keller, Nancy P.
通讯作者：
Keller, Nancy P.
影响因子：
2.9
作者：
Brosch, G;Dangl, M;Loidl, P
通讯作者：
Loidl, P