Intact feto-placental growth in microRNA-210 deficient mice.
Intact feto-placental growth in microRNA-210 deficient mice.
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DOI：
10.1016/j.placenta.2016.09.007
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发表时间：
2016-11
期刊：
影响因子：
3.8
通讯作者：
Sadovsky, Yoel
中科院分区：
文献类型：
--
作者：
Krawczynski, Kamil;Mishima, Takuya;Huang, Xin;Sadovsky, Yoel
MicroRNA-210 (miR-210) has been implicated in homeostatic adaptation during hypoxia. We hypothesized that miR-210 deficiency impacts feto-placental growth. As expected, mir-210 knockout (ko) mice exhibited markedly reduced placental miR-210 expression, compared to wild-type (wt) mice. Mating of mir-210 heterozygotes resulted in near Mendelian progeny distribution, with insignificant differences between wt and ko animals with regard to embryo or placental weight and gross morphology. Intriguingly, exposure of mice to non-severe hypoxia (O2=12%) between E11.5-E17.5 reduced placental miR-210 expression, with slight expression changes of some miR-210 target mRNAs. Thus, miR-210 is likely dispensable for feto-placental growth in normoxia or non-severe hypoxia.
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DOI：
10.4049/jimmunol.1301289
发表时间：
2013-09-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
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DOI：
10.1073/pnas.1304718110
发表时间：
2013-07-16
影响因子：
11.1
作者：
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通讯作者：
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影响因子：
21.3
作者：
通讯作者：
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影响因子：
9.8
作者：
Zhu, Xiao-ming;Han, Tao;Yao, Yuan-qing
通讯作者：
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