MiR-210 is induced by Oct-2, regulates B cells, and inhibits autoantibody production.
MiR-210 is induced by Oct-2, regulates B cells, and inhibits autoantibody production.
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DOI：
10.4049/jimmunol.1301289
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发表时间：
2013-09-15
期刊：
影响因子：
--
通讯作者：
Smith KGC
中科院分区：
文献类型：
--
作者：
Mok Y;Schwierzeck V;Thomas DC;Vigorito E;Rayner TF;Jarvis LB;Prosser HM;Bradley A;Withers DR;Mårtensson IL;Corcoran LM;Blenkiron C;Miska EA;Lyons PA;Smith KGC
MicroRNAs are small, non-coding RNAs that regulate gene expression post-transcriptionally. Here, we show that miR-210 is induced by Oct-2, a key transcriptional mediator of B-cell activation. Germline deletion of miR-210 results in the development of autoantibodies from 5 months of age. Overexpression of miR-210 in vivo resulted in cell autonomous expansion of the B1 lineage and impaired fitness of B2 cells. Mice over-expressing miR-210 exhibited impaired class-switched antibody responses, a finding confirmed in wild-type B-cells transfected with a miR-210 mimic. In vitro studies demonstrated a defect in cellular proliferation and cell-cycle entry, which was consistent with the transcriptomic analysis demonstrating down-regulation of genes involved in cellular proliferation and B cell activation. These findings indicate that Oct-2 induction of miR-210 provides a novel inhibitory mechanism for the control of B cells and autoantibody production.
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影响因子：
64.8
作者：
Baek, Daehyun;Villen, Judit;Shin, Chanseok;Camargo, Fernando D.;Gygi, Steven P.;Bartel, David P.
通讯作者：
Bartel, David P.
影响因子：
4.4
作者：
Higuchi, T;Aiba, Y;Tsubata, T
通讯作者：
Tsubata, T
DOI：
10.1073/pnas.88.24.11550
发表时间：
1991-12-01
影响因子：
11.1
作者：
HARDY, RR;HAYAKAWA, K
通讯作者：
HAYAKAWA, K
影响因子：
64.8
作者：
He, Lin;He, Xingyue;Hannon, Gregory J.
通讯作者：
Hannon, Gregory J.
影响因子：
15.3
作者：
Hayakawa, K;Hardy, R R;Herzenberg, L A;Herzenberg, L A
通讯作者：
Herzenberg, L A