Storage rates of circulating free fatty acid into adipose tissue during eating or walking in humans.
Storage rates of circulating free fatty acid into adipose tissue during eating or walking in humans.
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作者：
Koutsari C;Mundi MS;Ali AH;Jensen MD
我们测量了餐后和步行条件下皮下脂肪组织游离脂肪酸（FFA）的储存率，以更好地了解这一途径对体脂分布的贡献。棕榈酸示踪剂静脉输注和脂肪活检收集测量棕榈酸储存在上（UBSQ）和下半身皮下脂肪（LBSQ）在41（17名男性）和40（16名男性）志愿者餐后和吸收后步行条件下，分别。在UBSQ（0.50 ± 0.25 μmol·kg fat−1·min− 1）和LBSQ脂肪（0.37 ± 0.25 μmol·kg fat−1·min−1; P = 0.005）中，女性餐后棕榈酸盐储存量大于男性;在两种性别中，UBSQ脂肪的储存率均显著高于LBSQ脂肪。在行走过程中，UBSQ棕榈酸盐储存量在性别之间没有差异，而女性的LBSQ储存量大于男性（0.40 ± 0.22 vs. 0.25 ± 0.15 μmol/kg fat−1/min−1; P = 0.01）。仅在女性中，LBSQ中的行走棕榈酸酯储存量显著大于UBSQ脂肪。脂肪细胞CD 36和二酰基甘油酰基转移酶（DGAT）与LBSQ棕榈酸储存在餐后和步行条件下，分别。我们的结论是，UBSQ脂肪是首选餐后FFA储存库为两种性别，而步行有利于存储在LBSQ脂肪的妇女。跨膜转运（CD 36）和酯化成甘油三酯（DGAT）可能是喂养和运动期间LBSQ FFA储存的限速步骤。
We measured subcutaneous adipose tissue free fatty acid (FFA) storage rates in postprandial and walking conditions to better understand the contributions of this pathway to body fat distribution. Palmitate tracers were infused intravenously and fat biopsies collected to measure palmitate storage in upper- (UBSQ) and lower-body subcutaneous (LBSQ) fat in 41 (17 men) and 40 (16 men) volunteers under postprandial and under postabsorptive walking conditions, respectively. Postprandial palmitate storage was greater in women than men in UBSQ (0.50 ± 0.25 vs. 0.33 ± 0.37 μmol ⋅ kg fat−1 ⋅ min−1; P = 0.007) and LBSQ fat (0.37 ± 0.25 vs. 0.22 ± 0.20 μmol ⋅ kg fat−1 ⋅ min−1; P = 0.005); storage rates were significantly greater in UBSQ than LBSQ fat in both sexes. During walking, UBSQ palmitate storage did not differ between sexes, whereas LBSQ storage was greater in women than men (0.40 ± 0.22 vs. 0.25 ± 0.15 μmol ⋅ kg fat−1 ⋅ min−1; P = 0.01). In women only, walking palmitate storage was significantly greater in LBSQ than UBSQ fat. Adipocyte CD36 and diacylglycerol acyltransferase (DGAT) correlated with LBSQ palmitate storage in the postprandial and walking condition, respectively. We conclude that UBSQ fat is the preferred postprandial FFA storage depot for both sexes, whereas walking favors storage in LBSQ fat in women. Transmembrane transport (CD36) and esterification into triglycerides (DGAT) may be rate-limiting steps for LBSQ FFA storage during feeding and exercise.
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