Cutting Edge: Heterogeneity in Cell Age Contributes to Functional Diversity of NK Cells.
Cutting Edge: Heterogeneity in Cell Age Contributes to Functional Diversity of NK Cells.
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DOI：
10.4049/jimmunol.2001163
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发表时间：
2021-02-01
期刊：
影响因子：
--
通讯作者：
Sun JC
中科院分区：
文献类型：
--
作者：
Adams NM;Diaz-Salazar C;Dang C;Lanier LL;Sun JC
幼稚的自适应淋巴细胞之间的异质性决定了它们在免疫响应期间的脂肪决定，而自然杀手（NK）是可以在此期间对各种NK细胞的plosem sopters sopertim sopertim and sopers sopers sopers sopers of tyme sopers of time tyme'' （ILC1）为了表征他们的稳态营业额的动力，我们发现居住的ILC1的稳态离职比循环的NK细胞更慢。期间巨细胞病毒感染。
Heterogeneity among naïve adaptive lymphocytes determines their individual functions and fate decisions during an immune response. Natural killer (NK) cells are innate lymphocytes capable of generating ‘adaptive’ responses during infectious challenges. However, the factors that govern various NK cell functions are not fully understood. Here, we use a reporter mouse model to permanently ‘time-stamp’ NK cells and type 1 innate lymphoid cells (ILC1s) in order to characterize the dynamics of their homeostatic turnover. We found that the homeostatic turnover of tissue-resident ILC1s is much slower than that of circulating NK cells. NK cell homeostatic turnover is further accelerated without the transcription factor Eomes. Finally, heterogeneity in NK cell age diversifies NK cell function, with ‘older’ NK cells exhibiting more potent IFN-γ production to activating stimuli, and more robust adaptive responses during cytomegalovirus infection. These results provide insight into how the functional response of an NK cell varies over its lifespan.
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影响因子：
30.5
作者：
Lau CM;Adams NM;Geary CD;Weizman OE;Rapp M;Pritykin Y;Leslie CS;Sun JC
通讯作者：
Sun JC
DOI：
10.1038/nri3044
发表时间：
2011-08-26
期刊：
Nature reviews. Immunology
影响因子：
--
作者：
通讯作者：
--
影响因子：
25
作者：
Madisen L;Zwingman TA;Sunkin SM;Oh SW;Zariwala HA;Gu H;Ng LL;Palmiter RD;Hawrylycz MJ;Jones AR;Lein ES;Zeng H
通讯作者：
Zeng H
影响因子：
64.8
作者：
Sun, Joseph C.;Beilke, Joshua N.;Lanier, Lewis L.
通讯作者：
Lanier, Lewis L.
影响因子：
4.4
作者：
Jamieson, AM;Isnard, P;Raulet, DH
通讯作者：
Raulet, DH