Epigenetic control of innate and adaptive immune memory.
Epigenetic control of innate and adaptive immune memory.
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DOI：
10.1038/s41590-018-0176-1
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发表时间：
2018-09
影响因子：
30.5
通讯作者：
Sun JC
中科院分区：
文献类型：
--
作者：
Lau CM;Adams NM;Geary CD;Weizman OE;Rapp M;Pritykin Y;Leslie CS;Sun JC
克隆膨胀和免疫记忆是哺乳动物适应性免疫的标志性特征，对于延长病原体的宿主控制至关重要。阶段。记忆。
Clonal expansion and immunological memory are hallmark features of the mammalian adaptive immune response and essential for prolonged host control of pathogens. Recent work demonstrates that natural killer (NK) cells of the innate immune system also exhibit these adaptive traits during infection. Here we demonstrate that differentiating and ‘memory’ NK cells possess distinct chromatin accessibility states and that their epigenetic profiles reveal a ‘poised’ regulatory program at the memory stage. Furthermore, we elucidate how individual STAT transcription factors differentially control epigenetic and transcriptional states early during infection. Finally, concurrent chromatin profiling of the canonical CD8+ T cell response against the same infection demonstrated parallel and distinct epigenetic signatures defining NK cells and CD8+ T cells. Overall, our study reveals the dynamic nature of epigenetic modifications during the generation of innate and adaptive lymphocyte memory.
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影响因子：
64.5
作者：
Kaech, SM;Hemby, S;Ahmed, R
通讯作者：
Ahmed, R
DOI：
10.4049/jimmunol.181.9.6394
发表时间：
2008-11-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Fodil-Cornu N;Lee SH;Belanger S;Makrigiannis AP;Biron CA;Buller RM;Vidal SM
通讯作者：
Vidal SM
影响因子：
48
作者：
Langmead, Ben;Salzberg, Steven L.
通讯作者：
Salzberg, Steven L.
影响因子：
30.5
作者：
通讯作者：
--
影响因子：
20.3
作者：
Gil, M. Pilar;Ploquin, Mickael J. Y.;Biron, Christine A.
通讯作者：
Biron, Christine A.