Mechanics of Microsporidian Polar Tube Firing.

Mechanics of Microsporidian Polar Tube Firing.
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微孢子虫极管发射的力学。

DOI:
10.1007/978-3-030-93306-7_9
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发表时间:
2022
影响因子:
--
通讯作者:
Bhabha,Gira
Bhabha,Gira
中科院分区:
--
文献类型:
--
作者:
Jaroenlak,Pattana;Usmani,Mahrukh;Ekiert,DamianC;Bhabha,Gira

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作为基因组减少的专性细胞内寄生虫,微孢子虫必须感染宿主细胞才能复制并引起疾病。它们可以利用一种称为极管(PT)的鱼叉状入侵细胞器来启动感染。 PT 在视觉上和功能上都是一个引人注目的细胞器,是微孢子虫门的一个特征。在宿主体外,微孢子虫以可传播的单细胞孢子形式存在。在每个孢子内部,PT 排列成紧密的线圈。萌发后,PT 经历巨大的构象变化,变成长长的线性管,并充当将感染性物质从孢子传递到宿主细胞的隧道。发射过程极其迅速,发生在毫秒级的时间内,并且出现的管子可能长达孢子体大小的 20 倍。在本章中,我们将讨论有关 PT 结构的已知信息、PT 发射过程的机制,以及它如何使材料从孢子体中移动。
As obligate intracellular parasites with reduced genomes, microsporidia must infect host cells in order to replicate and cause disease. They can initiate infection by utilizing a harpoon-like invasion organelle called the polar tube (PT). The PT is both visually and functionally a striking organelle and is a characteristic feature of the microsporidian phylum. Outside the host, microsporidia exist as transmissible, single-celled spores. Inside each spore, the PT is arranged as a tight coil. Upon germination, the PT undergoes a large conformational change into a long, linear tube and acts as a tunnel for the delivery of infectious cargo from the spore to a host cell. The firing process is extremely rapid, occurring on a millisecond timescale, and the emergent tube may be as long as 20 times the size of the spore body. In this chapter, we discuss what is known about the structure of the PT, the mechanics of the PT firing process, and how it enables movement of material from the spore body.
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