Techniques for early diagnosis of oral squamous cell carcinoma: Systematic review.

Techniques for early diagnosis of oral squamous cell carcinoma: Systematic review.
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DOI:
10.4317/medoral.20347
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发表时间:
2015-05-01
期刊:
Medicina oral, patologia oral y cirugia bucal
影响因子:
--
通讯作者:
Gay-Escoda C
Gay-Escoda C
中科院分区:
其他
文献类型:
--
作者:
Carreras-Torras C;Gay-Escoda C

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鉴于晚期疾病的死亡率,早期口腔潜在恶性疾病(OPMD)和口腔鳞状细胞癌(OSCC)的诊断具有重要的临床意义。这项研究的目的是回顾文献,以评估这一领域的现状和进展。计算机检索Cochrane和PubMed(2006年1月至2013年12月),检索词“鳞状细胞癌”、“早期诊断”、“口腔”、“潜在恶性疾病”或“癌前病变”。纳入标准为使用早期诊断口腔鳞状细胞癌和口腔PMD的技术,7岁以前的文章和以英语、法语或西班牙语撰写的出版物。排除标准为病例报告和其他语言的研究。在最初通过检索获得的89篇研究中,60篇文章被选入系统评价:1篇荟萃分析,17篇系统综述,35篇前瞻性研究,5篇回顾研究,1篇共识研究和1篇半结构化访谈。最好的诊断技术是我们有足够的经验和培训的。当然,组织活检和组织病理学检查仍应是口腔癌诊断的金标准。在这篇系统性综述中,对于大多数拟议的口腔鳞状细胞癌早期诊断技术还没有找到足够的科学证据,因此需要更广泛和详尽的研究。关键词:鳞癌,早期诊断,口腔,潜在恶性疾病,癌前病变。
The diagnosis of early oral potentially malignant disorders (OPMD) and oral squamous cell carcinoma (OSCC) is of paramount clinical importance given the mortality rate of late stage disease. The aim of this study is to review the literature to assess the current situation and progress in this area. A search in Cochrane and PubMed (January 2006 to December 2013) has been used with the key words “squamous cell carcinoma”, “early diagnosis” “oral cavity”, “Potentially Malignant Disorders” y “premalignant lesions”. The inclusion criteria were the use of techniques for early diagnosis of OSCC and OPMD, 7 years aged articles and publications written in English, French or Spanish. The exclusion criteria were case reports and studies in other languages. Out of the 89 studies obtained initially from the search 60 articles were selected to be included in the systematic review: 1 metaanalysis, 17 systematic reviews, 35 prospective studies, 5 retrospective studies, 1 consensus and 1 semi-structured interviews. The best diagnostic technique is that which we have sufficient experience and training. Definitely tissue biopsy and histopathological examination should remain the gold standard for oral cancer diagnose. In this systematic review it has not been found sufficient scientific evidence on the majority of proposed techniques for early diagnosis of OSCC, therefore more extensive and exhaustive studies are needed. Key words: Squamous cell carcinoma, early diagnosis, oral cavity, potentially malignant disorders, premalignant lesions.
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